{"id":"W2982555809","doi":"10.1126/scitranslmed.aax2863","title":"Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response","year":2019,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":207,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research; Leukemia and Lymphoma Society of Canada; Cancer Research Society","keywords":"Venetoclax; Azacitidine; Cancer research; Integrated stress response; Myeloid leukemia; Pharmacology; Medicine; Chemistry; Biology; Leukemia; Translation (biology); Biochemistry; Immunology; Chronic lymphocytic leukemia; Gene; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009106028,0.0003308453,0.0002973747,0.0001951286,0.0001323704,0.0002995706,0.0002036997,0.0001725693,0.0009264462],"category_scores_gemma":[0.00007305045,0.00008839231,0.0001803871,0.0001253356,0.0001669295,0.0001463837,0.0001924393,0.0006387688,0.0001657869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000244542,"about_ca_system_score_gemma":0.0002182964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005648701,"about_ca_topic_score_gemma":0.001349261,"domain_scores_codex":[0.9999158,0.000008684157,0.000008690628,0.00002363074,0.00002375733,0.00001938449],"domain_scores_gemma":[0.9999541,0.000006961187,0.00001716416,0.000005932805,0.00000439897,0.00001143875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001151922,0.00005607457,0.0001964932,0.00004433799,0.000006420614,0.00003523238,0.00001079455,0.0001935192,0.9945815,0.0001495808,0.00007706946,0.004533753],"study_design_scores_gemma":[0.00006093798,0.0009784842,0.003391807,0.000008368309,0.00003522894,0.0003431211,0.00002066989,0.001447921,0.9864385,0.00006260659,0.007204209,0.000008041179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912331,0.003067994,0.003081695,0.0001426039,0.00005211737,0.00006002157,0.0003287347,0.0002564583,0.001777324],"genre_scores_gemma":[0.9949791,0.001366084,0.001682448,0.00004600207,0.00001082293,0.00002374071,0.0003993759,0.00001777329,0.001474723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009264462,"threshold_uncertainty_score":0.003099263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02854767751217464,"score_gpt":0.3221929801378633,"score_spread":0.2936453026256887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}