{"id":"W2982561040","doi":"10.2147/cmar.s213051","title":"<p>Population-Based Analysis Of The Use Of Radium-223 For Bone-Metastatic Castration-Resistant Prostate Cancer In Ontario, And Of Factors Associated With Treatment Completion And Outcome</p>","year":2019,"lang":"en","type":"article","venue":"Cancer Management and Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Regional Municipality of Durham; Princess Margaret Cancer Centre; Juravinski Cancer Centre; Sunnybrook Health Science Centre","funders":"Sanofi Genzyme; Bayer Canada; Astellas Pharma; Endocyte; Bavarian Nordic; Sanofi; Exelixis; Genentech; AstraZeneca; Amgen","keywords":"Medicine; Prostate cancer; Discontinuation; Enzalutamide; Radium-223; Proportional hazards model; Internal medicine; Cohort; Hazard ratio; Docetaxel; Prostate-specific antigen; Abiraterone acetate; Oncology; Population; Cancer; Androgen deprivation therapy; Bone metastasis; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004130534,0.0001550957,0.0005724127,0.0006072071,0.00009196296,0.00002765687,0.000051706,0.0000410839,0.00007475811],"category_scores_gemma":[0.00002769647,0.00008962851,0.00007211987,0.0008948414,0.0002286538,0.00008151627,0.00004337363,0.00009621826,4.193129e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005848776,"about_ca_system_score_gemma":0.0002412221,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02387793,"about_ca_topic_score_gemma":0.1971058,"domain_scores_codex":[0.9983262,0.0001163961,0.0003931633,0.0003092813,0.0005750265,0.0002798685],"domain_scores_gemma":[0.9989153,0.0002935549,0.0001915417,0.0002205865,0.0003045367,0.00007445867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001585102,0.0002396292,0.9888299,0.0005846565,0.001649777,0.000003387387,0.0007478811,0.00114412,0.003145798,0.0001242417,0.00002641406,0.001919109],"study_design_scores_gemma":[0.006313415,0.0006798859,0.9867155,0.0003549368,0.0009722617,8.160853e-8,0.000197829,0.003439627,0.0008117124,0.0000154748,0.0004137365,0.0000855648],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952623,0.00119806,0.000006557913,0.0003992434,0.00002378617,0.002724098,0.0003383016,0.000003764883,0.00004394499],"genre_scores_gemma":[0.9953075,0.001064057,0.00007815444,0.000008379478,0.000003433375,0.0002527192,0.0001992246,0.00001382459,0.003072679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1732278,"threshold_uncertainty_score":0.9826221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1496487276642577,"score_gpt":0.3775254693243324,"score_spread":0.2278767416600747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}