{"id":"W2982561040","doi":"10.2147/cmar.s213051","title":"<p>Population-Based Analysis Of The Use Of Radium-223 For Bone-Metastatic Castration-Resistant Prostate Cancer In Ontario, And Of Factors Associated With Treatment Completion And Outcome</p>","year":2019,"lang":"en","type":"article","venue":"Cancer Management and Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Regional Municipality of Durham; Princess Margaret Cancer Centre; Juravinski Cancer Centre; Sunnybrook Health Science Centre","funders":"Sanofi Genzyme; Bayer Canada; Astellas Pharma; Endocyte; Bavarian Nordic; Sanofi; Exelixis; Genentech; AstraZeneca; Amgen","keywords":"Medicine; Prostate cancer; Discontinuation; Enzalutamide; Radium-223; Proportional hazards model; Internal medicine; Cohort; Hazard ratio; Docetaxel; Prostate-specific antigen; Abiraterone acetate; Oncology; Population; Cancer; Androgen deprivation therapy; Bone metastasis; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004842699,0.0002651769,0.0002627253,0.0008792488,0.000825013,0.0006144529,0.0007619595,0.0003304176,0.001378172],"category_scores_gemma":[0.001594134,0.000404832,0.0005013418,0.00231525,0.0006846961,0.0002956277,0.0005896324,0.000345136,0.0001963185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006408061,"about_ca_system_score_gemma":0.005792766,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.7762674,"about_ca_topic_score_gemma":0.805231,"domain_scores_codex":[0.999455,0.00005865599,0.000054042,0.00013455,0.0001672256,0.0001304378],"domain_scores_gemma":[0.9977701,0.0001377475,0.00129349,0.0001202152,0.0003225701,0.0003558488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004826445,0.000009767494,0.9991181,0.00001065512,0.00002510205,0.0000317019,0.0001303971,0.00003223579,0.0001043705,0.000005473803,0.0001003811,0.0003834651],"study_design_scores_gemma":[0.000004192545,0.00002393635,0.9995896,0.000003096626,0.000009654958,0.00003425237,0.0001551128,0.00006185137,0.00001481967,0.000002165821,0.00009936964,0.000001892668],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983076,0.000101327,0.00003687297,0.00003534272,0.000001466745,0.00002004001,0.001222866,0.000003513938,0.0002711533],"genre_scores_gemma":[0.999111,0.0000751231,0.00003437543,0.00001525124,0.000002662083,0.00001232324,0.0005922099,0.000001443608,0.0001556533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2237326,"threshold_uncertainty_score":0.4501004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1496487276642577,"score_gpt":0.3775254693243324,"score_spread":0.2278767416600747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}