{"id":"W2982588193","doi":"10.1002/stem.3082","title":"Developing a simple method to enhance the generation of cone and rod photoreceptors in pluripotent stem cell-derived retinal organoids","year":2019,"lang":"en","type":"article","venue":"Stem Cells","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; Medical Research Council Canada; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Retina UK","keywords":"Biology; Induced pluripotent stem cell; Organoid; Retinal; Stem cell; Cell biology; Cone (formal languages); Simple (philosophy); Human Induced Pluripotent Stem Cells; Retina; Neuroscience; Embryonic stem cell; Genetics; Botany; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003346583,0.0001210011,0.0001480439,0.00003353377,0.00003522537,0.00001622573,0.0001147649,0.00007371862,0.00002126658],"category_scores_gemma":[0.000004126929,0.00009514762,0.00002791623,0.000113112,0.00002120314,0.000003549595,0.00009299992,0.0000485249,0.00001152523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001839673,"about_ca_system_score_gemma":0.00008253541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000285649,"about_ca_topic_score_gemma":0.00003252379,"domain_scores_codex":[0.9990927,0.00009731713,0.0002471374,0.0002842312,0.0001142177,0.0001644208],"domain_scores_gemma":[0.9996213,0.00001773173,0.00008953801,0.0001577346,0.00007670445,0.00003694315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005228009,0.000009464854,0.001824962,0.00004040903,0.000009620391,3.417603e-7,0.0004716537,0.00009934096,0.9932738,0.00001421241,0.0002760897,0.003927848],"study_design_scores_gemma":[0.0002515585,0.0001171173,0.0009144472,0.00001998576,0.000004537874,9.98567e-7,0.000780208,0.00009301306,0.9915166,0.000006725943,0.006154585,0.0001401443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912322,0.0003518329,0.007439077,0.0001537194,0.0001041694,0.0004008268,0.000003723604,0.000003587144,0.0003108227],"genre_scores_gemma":[0.9921822,0.0001416469,0.006335666,0.0002105805,0.00002865368,0.0000182007,0.00001701908,0.00001324639,0.001052799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005878496,"threshold_uncertainty_score":0.3880008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134307505194301,"score_gpt":0.2542919121418025,"score_spread":0.2429488370898595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}