{"id":"W2982666528","doi":"10.1016/j.metabol.2019.153992","title":"SIRT1 activation rescues the mislocalization of RNA-binding proteins and cognitive defects induced by inherited cobalamin disorders","year":2019,"lang":"en","type":"article","venue":"Metabolism","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Conseil Régional de Lorraine; Fondation Jérôme Lejeune; McGill University","keywords":"Cobalamin; Cell biology; Endoplasmic reticulum; Biology; Phosphorylation; RNA-binding protein; Molecular biology; Chemistry; Biochemistry; Messenger RNA; Vitamin B12","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002390358,0.0007061552,0.0005676754,0.0005170879,0.0003223735,0.0004118973,0.0007694715,0.0008383025,0.003913764],"category_scores_gemma":[0.0003213725,0.0002762646,0.0005228576,0.0002387957,0.0006714403,0.0002031362,0.0004747841,0.001077828,0.0009847826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004599971,"about_ca_system_score_gemma":0.0005645835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002752703,"about_ca_topic_score_gemma":0.002704852,"domain_scores_codex":[0.9997358,0.00003589502,0.00003744335,0.00006412687,0.00006173365,0.00006507253],"domain_scores_gemma":[0.9996401,0.00004578055,0.00009974192,0.00005334199,0.00003320815,0.000127827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004568554,0.00005617403,0.0001868468,0.00006535657,0.00003100465,0.0002767864,0.00002716093,0.0001041194,0.9964701,0.0002222711,0.0001936675,0.001909633],"study_design_scores_gemma":[0.0001196149,0.0003146369,0.00494453,0.00001862982,0.00007930079,0.0009158821,0.0001004924,0.001226884,0.9844273,0.0002389858,0.007592999,0.00002086501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986053,0.00245037,0.006028793,0.0007269664,0.0003095838,0.00003841311,0.001530873,0.0007943183,0.002067677],"genre_scores_gemma":[0.9926183,0.0007085034,0.001795196,0.00009761578,0.00002215111,0.00002451902,0.0006431846,0.0001236017,0.003966996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003913764,"threshold_uncertainty_score":0.01309282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0146224801561148,"score_gpt":0.278958137672816,"score_spread":0.2643356575167012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}