{"id":"W2982688710","doi":"10.4049/jimmunol.1900556","title":"Ubc9 Interacts with and SUMOylates the TCR Adaptor SLP-76 for NFAT Transcription in T Cells","year":2019,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"SUMO protein; NFAT; T-cell receptor; Cell biology; Signal transducing adaptor protein; Biology; Transcription factor; T cell; Transcription (linguistics); Signal transduction; Molecular biology; Chemistry; Immune system; Ubiquitin; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001445409,0.0004245413,0.0002296037,0.0002187777,0.000440304,0.000392629,0.0001815775,0.000297909,0.001702323],"category_scores_gemma":[0.0001210809,0.0001751029,0.0003655623,0.0001886486,0.0002135918,0.000212594,0.000355604,0.0003987901,0.0008579837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006591637,"about_ca_system_score_gemma":0.0002811883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007288765,"about_ca_topic_score_gemma":0.001215385,"domain_scores_codex":[0.9997261,0.0000374682,0.00001788111,0.00005587657,0.00008016767,0.00008240855],"domain_scores_gemma":[0.9999151,0.000006694375,0.00001856073,0.00001418428,0.000008935574,0.00003641146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006715704,0.00001634254,0.0003948507,0.00002414412,0.000007835913,0.0001131941,0.000006052296,0.00005737463,0.9983239,0.00006873331,0.00004247413,0.000877898],"study_design_scores_gemma":[0.00001322849,0.00008304635,0.010828,0.000004534758,0.00001435899,0.0004879762,0.00001952142,0.001089039,0.984087,0.00005826108,0.003309973,0.00000504116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931341,0.002052741,0.00216139,0.000108851,0.00004709872,0.00001563035,0.0001768482,0.00006821258,0.002235063],"genre_scores_gemma":[0.9954104,0.0005481342,0.0009098009,0.00004150108,0.00001529046,0.00001342705,0.0003318778,0.000008879146,0.002720641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001702323,"threshold_uncertainty_score":0.005694807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009160418772040714,"score_gpt":0.218228716270034,"score_spread":0.2090682974979933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}