{"id":"W2982697290","doi":"10.1194/jlr.ra119000100","title":"CXCL12 promotes atherosclerosis by downregulating ABCA1 expression via the CXCR4/GSK3β/β-cateninT120/TCF21 pathway","year":2019,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Natural Science Foundation of China","keywords":"ABCA1; Gene knockdown; CXC chemokine receptors; Chemokine; Phosphorylation; Chemistry; GSK-3; Cell biology; Signal transduction; Transcription factor; Chemotaxis; Chemokine receptor; Cancer research; Biology; Receptor; Biochemistry; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004960365,0.0002455583,0.0006361755,0.0003124079,0.000298695,0.0001514152,0.0005687625,0.0002035474,0.000543469],"category_scores_gemma":[0.0005192701,0.0001316733,0.0003320586,0.0005665787,0.0002204508,0.000336971,0.0002516069,0.001879569,0.0002303766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001162423,"about_ca_system_score_gemma":0.0002495497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003082258,"about_ca_topic_score_gemma":0.000001464496,"domain_scores_codex":[0.9953542,0.000612374,0.0008609209,0.0003268288,0.002114905,0.0007307323],"domain_scores_gemma":[0.997013,0.0005512366,0.000432396,0.0006555432,0.0009452563,0.0004026137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003659826,0.0003200487,0.01385378,0.0001104274,0.0000728731,0.000008058426,0.001329453,0.00001021707,0.9526234,0.0000162553,0.01311036,0.01817918],"study_design_scores_gemma":[0.006965191,0.002362227,0.1212074,0.002405724,0.00009515342,0.0006594596,0.001941097,0.0005842054,0.5907087,0.0003224397,0.2723294,0.0004189493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899212,0.001129043,0.00008968786,0.00600751,0.0008484449,0.0006632308,0.00000707286,0.00003026435,0.001303572],"genre_scores_gemma":[0.990364,0.0002813066,0.0006433318,0.0002391704,0.002926375,0.00001518098,0.000004541997,0.00007781282,0.005448293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3619147,"threshold_uncertainty_score":0.8165895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04827161738810415,"score_gpt":0.3365995547764038,"score_spread":0.2883279373882996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}