{"id":"W2982734891","doi":"10.1093/neuonc/noz175.442","title":"GENE-40. CHARACTERIZING EPIGENETIC INTRATUMORAL HETEROGENEITY IN GLIOMA USING SINGLE-CELL BISULFITE SEQUENCING","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Epigenetics; Biology; Glioma; Epigenomics; DNA methylation; Genetics; Bisulfite sequencing; Epigenome; Computational biology; Cancer research; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176053,0.0001578978,0.0001657443,0.0004132273,0.0001157007,0.0002338005,0.0001154931,0.0001508283,0.0006858031],"category_scores_gemma":[0.0002058287,0.0001091383,0.0001662431,0.0002047797,0.0001521547,0.00008931807,0.000124591,0.000170971,0.0002213136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002065865,"about_ca_system_score_gemma":0.0002244472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001081266,"about_ca_topic_score_gemma":0.003434808,"domain_scores_codex":[0.9999076,0.00001135761,0.000005171109,0.00003722127,0.00002698446,0.00001169353],"domain_scores_gemma":[0.999911,0.00001708901,0.00002491392,0.00001655824,0.00002004706,0.00001050705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005021281,0.00001063449,0.003130499,0.00003000881,0.00001300123,0.00001853388,0.00003969479,0.000350428,0.9899025,0.0001035493,0.00004758907,0.006303367],"study_design_scores_gemma":[0.00001248788,0.0003085269,0.09554075,0.00001156547,0.00007826938,0.0004720441,0.00008116666,0.01027457,0.8866851,0.0005261063,0.005998363,0.00001110881],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970549,0.0007100426,0.02538703,0.00005637703,0.000009678382,0.00005686202,0.002107415,0.0001880726,0.000935543],"genre_scores_gemma":[0.9644907,0.0003695373,0.02950357,0.00004498006,0.000004539569,0.00007683116,0.003487288,0.00005773445,0.001964981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001081266,"threshold_uncertainty_score":0.002294242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0484672198673101,"score_gpt":0.297158030611291,"score_spread":0.2486908107439809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}