{"id":"W2982755933","doi":"10.1182/blood-2019-127253","title":"Results from a Global Randomized Phase 3 Study of Guadecitabine (G) Vs Treatment Choice (TC) in 815 Patients with Treatment Naïve (TN) AML Unfit for Intensive Chemotherapy (IC) ASTRAL-1 Study: Analysis By Number of Cycles","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Alberta","funders":"","keywords":"Decitabine; Medicine; Internal medicine; Discontinuation; Clinical endpoint; Randomization; Cytarabine; Azacitidine; Surrogate endpoint; Gastroenterology; Chemotherapy regimen; Oncology; Phases of clinical research; Chemotherapy; Randomized controlled trial; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006881203,0.0014649,0.002917174,0.0005143436,0.000371309,0.0009425828,0.0008883456,0.001431423,0.004791502],"category_scores_gemma":[0.004019499,0.0005785846,0.003587451,0.0007289859,0.001574048,0.001127881,0.0005843271,0.002733244,0.000676356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009739905,"about_ca_system_score_gemma":0.001260543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005381497,"about_ca_topic_score_gemma":0.001441159,"domain_scores_codex":[0.996603,0.00255684,0.0001380029,0.000368844,0.0001317208,0.0002014389],"domain_scores_gemma":[0.9960266,0.001614175,0.0008267124,0.0004582757,0.0001716374,0.0009024186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9746037,0.004906678,0.002946306,0.000284708,0.001590252,0.00002979854,0.00006384606,0.000624523,0.002469072,0.0000609836,0.0007222068,0.01169784],"study_design_scores_gemma":[0.8184711,0.1607338,0.01561401,0.00003820704,0.002255817,0.00007843739,0.00004262433,0.0006779742,0.0007663889,0.0002619092,0.001028797,0.00003090585],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875448,0.003581237,0.0009601749,0.0005178816,0.000137689,0.003083097,0.00228564,0.00009137842,0.001798088],"genre_scores_gemma":[0.9866931,0.001284004,0.002132964,0.00136031,0.0001925549,0.003531827,0.003577454,0.00006604775,0.001161831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006881203,"threshold_uncertainty_score":0.03639174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01590465419755142,"score_gpt":0.3327207944183557,"score_spread":0.3168161402208042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}