{"id":"W2982996777","doi":"10.1182/blood-2019-123757","title":"An Individualized Risk Mitigation Approach for Safety: Experience from the Mosunetuzumab (CD20/CD3 Bispecific Antibody) Development Program in Relation to Neurotoxicity Risk","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); Jewish General Hospital","funders":"","keywords":"Medicine; Adverse effect; Cytokine release syndrome; Internal medicine; Clinical trial; Rituximab; CD20; Oncology; Antibody; Immunology; Chimeric antigen receptor; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000780085,0.0001573912,0.0002411573,0.00009582355,0.0001870889,0.00004898287,0.0001560727,0.000250481,0.00002741244],"category_scores_gemma":[0.0001653119,0.0001081035,0.00005732556,0.0004408766,0.0001221484,0.0001085788,0.00003900257,0.000361458,0.00001047909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005458189,"about_ca_system_score_gemma":0.0001384763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001911784,"about_ca_topic_score_gemma":0.000045185,"domain_scores_codex":[0.9981505,0.000186762,0.0004570143,0.0004714813,0.0004908134,0.0002433844],"domain_scores_gemma":[0.999019,0.0001570732,0.00020272,0.0003878071,0.000091323,0.0001420232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000926671,0.003634296,0.7392901,0.0001132434,0.0001550887,0.000003175114,0.02804788,0.0004688527,0.02791854,0.0007145378,0.00004281971,0.1986848],"study_design_scores_gemma":[0.004718365,0.0004362907,0.9714645,0.00008804114,0.00007798609,0.000002026938,0.0005847305,0.01245894,0.005145148,0.0004025936,0.004452717,0.0001686255],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798746,0.00007437963,0.01518195,0.0005072582,0.0001172534,0.003961545,0.00004669066,0.00007877959,0.0001575986],"genre_scores_gemma":[0.9396791,0.00005051783,0.058598,0.0001655317,0.0001271749,0.0003534558,0.0009754304,0.00002260006,0.00002822634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2321745,"threshold_uncertainty_score":0.4408333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02149087881260859,"score_gpt":0.3128144969756654,"score_spread":0.2913236181630568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}