{"id":"W2983035886","doi":"10.1182/blood-2019-125780","title":"Prognostic Impact of a Composite Genetic Profile Defined By Cytogenetics and Next Generation Sequencing at Diagnosis on Treatment Outcomes Following Allogeneic Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Oncology; Internal medicine; NPM1; Transplantation; Hematopoietic stem cell transplantation; Myeloid; Fludarabine; Myeloid leukemia; Hazard ratio; Proportional hazards model; Chemotherapy; Cyclophosphamide; Biology; Karyotype; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008994018,0.0001763914,0.0001969924,0.0005039443,0.0002065662,0.0004742563,0.0002986877,0.000237342,0.001199264],"category_scores_gemma":[0.002171601,0.00008559183,0.0002358089,0.0005427679,0.0002156535,0.0003338263,0.0004530529,0.0003491273,0.0001445307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003555025,"about_ca_system_score_gemma":0.0003886575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007522011,"about_ca_topic_score_gemma":0.001529627,"domain_scores_codex":[0.9995821,0.000107134,0.00005889699,0.00009996973,0.00009116717,0.00006072116],"domain_scores_gemma":[0.9984248,0.0002981052,0.0008907751,0.00007643981,0.00009609047,0.0002138986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006030635,0.00003315483,0.9931679,0.00001628484,0.00004556786,0.00007722342,0.00002835815,0.0001965017,0.0005199293,0.00003136822,0.000140793,0.005139795],"study_design_scores_gemma":[0.00001811537,0.0002674445,0.9969104,0.00001425824,0.00006607366,0.0004764198,0.00007134604,0.001208994,0.0004461178,0.0001425648,0.0003714341,0.00000701047],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990506,0.0002318918,0.0001421269,0.00004011316,0.000005841673,0.000006910653,0.0003289215,0.000003275538,0.0001904107],"genre_scores_gemma":[0.9991744,0.00006660202,0.0001466646,0.000018999,0.000009534455,0.000008253161,0.0005044359,0.000001331778,0.00006976877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001199264,"threshold_uncertainty_score":0.00475657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03108196507504248,"score_gpt":0.280488176020727,"score_spread":0.2494062109456845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}