{"id":"W2983057821","doi":"10.3390/cancers11111757","title":"Structural Implications of STAT3 and STAT5 SH2 Domain Mutations","year":2019,"lang":"en","type":"review","venue":"Cancers","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Research, Development and Innovation Office; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Hungarian Scientific Research Fund; Austrian Science Fund; Canada Research Chairs; Canada Foundation for Innovation; Canadian Cancer Society","keywords":"SH2 domain; HAMP domain; Biology; Computational biology; STAT5; Proto-oncogene tyrosine-protein kinase Src; STAT protein; Genetics; Transcription factor; stat; Signal transduction; Cell biology; STAT3; Protein domain; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004533882,0.0001785043,0.0008139592,0.0001601136,0.00005471649,0.00001190291,0.00006439405,0.00008979064,0.0002876212],"category_scores_gemma":[0.00003092378,0.0001422096,0.0002132599,0.0002040704,0.00009886269,0.0000449546,0.00002259941,0.0002336374,0.00001362915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000580752,"about_ca_system_score_gemma":0.001652454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000158825,"about_ca_topic_score_gemma":0.00002692514,"domain_scores_codex":[0.9991102,0.0000256065,0.0003926733,0.0002356692,0.00009479203,0.0001410961],"domain_scores_gemma":[0.9991107,0.0001191888,0.0002687057,0.0003043686,0.0001027201,0.00009431402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001555079,0.00000988847,0.00006826691,0.01658442,0.0005399176,0.000003697798,0.0004531865,0.00003493976,0.0001372945,0.003018051,0.004047244,0.9750875],"study_design_scores_gemma":[0.0002553671,0.0001066872,0.0001100597,0.003985316,0.000943292,0.00009044394,0.0001193462,0.00001385053,0.000008193225,0.000153548,0.9940742,0.000139669],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000726313,0.9948017,0.00007640415,0.00007014743,0.0002676254,0.0007473393,0.0009951759,0.0000232988,0.002291979],"genre_scores_gemma":[0.0008838936,0.9973236,0.0005303563,0.00004847447,0.0001122044,0.00008524639,0.0005704721,0.0000352233,0.000410585],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.990027,"threshold_uncertainty_score":0.5799141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08493529484834018,"score_gpt":0.3967468627922917,"score_spread":0.3118115679439515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}