{"id":"W2983057821","doi":"10.3390/cancers11111757","title":"Structural Implications of STAT3 and STAT5 SH2 Domain Mutations","year":2019,"lang":"en","type":"review","venue":"Cancers","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Research, Development and Innovation Office; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Hungarian Scientific Research Fund; Austrian Science Fund; Canada Research Chairs; Canada Foundation for Innovation; Canadian Cancer Society","keywords":"SH2 domain; HAMP domain; Biology; Computational biology; STAT5; Proto-oncogene tyrosine-protein kinase Src; STAT protein; Genetics; Transcription factor; stat; Signal transduction; Cell biology; STAT3; Protein domain; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002509931,0.0004215016,0.0005663794,0.00164504,0.0001289979,0.0004270408,0.0003814084,0.0005640007,0.002078788],"category_scores_gemma":[0.0004104512,0.0001315196,0.0003028316,0.001006595,0.0002441834,0.0005009567,0.0003198833,0.0008351651,0.0008859256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003917315,"about_ca_system_score_gemma":0.0006301095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007725949,"about_ca_topic_score_gemma":0.001306187,"domain_scores_codex":[0.9999189,0.00001168374,0.00001505804,0.00001757157,0.00002713807,0.000009633816],"domain_scores_gemma":[0.9998579,0.00006851825,0.00002393693,0.000003146532,0.00003444315,0.00001206456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008520091,0.00003063614,0.0002714412,0.01058704,0.00005648718,0.0003951848,0.00004517626,0.000357024,0.002716806,0.003054545,0.01939993,0.9630005],"study_design_scores_gemma":[0.00001410256,0.00008393942,0.001684731,0.003023708,0.0001302772,0.00485922,0.00005263677,0.0001020727,0.001246004,0.002057526,0.9867307,0.00001514075],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002341578,0.9985266,0.00006404778,0.000236058,0.0001071534,0.000001566742,0.00001818181,0.000004394727,0.000807879],"genre_scores_gemma":[0.001773188,0.9970137,0.000106281,0.0002348959,0.0001225231,0.000002783866,0.00004510822,0.000001305751,0.0007003569],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002078788,"threshold_uncertainty_score":0.006954312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08493529484834018,"score_gpt":0.3967468627922917,"score_spread":0.3118115679439515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}