{"id":"W2983081583","doi":"10.1182/blood-2019-126661","title":"Low-Dose Tamoxifen (LDTam) As a Breast Cancer (BC) Risk-Reduction Strategy in Lymphoma Survivors Exposed to Chest Radiation Therapy (RT) during Adolescence/Young Adulthood - a Randomized, Placebo-Controlled Double Blinded Phase IIb Trial","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Cancer Risks and Factors","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Tamoxifen; Breast cancer; Cumulative incidence; Internal medicine; Population; Oncology; Randomized controlled trial; Placebo; Clinical endpoint; Cancer; Pathology; Cohort","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009545268,0.0005050128,0.001642422,0.0004937318,0.0001314521,0.0001205645,0.0001806543,0.000286327,0.0004321933],"category_scores_gemma":[0.0001028224,0.0004167482,0.0004741585,0.0006359639,0.00006211589,0.000319109,0.0000290909,0.0003429765,0.00006108391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004136386,"about_ca_system_score_gemma":0.00083764,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02012406,"about_ca_topic_score_gemma":0.002097109,"domain_scores_codex":[0.9965655,0.0003550416,0.001028186,0.0007906879,0.0006176571,0.000642939],"domain_scores_gemma":[0.9982643,0.0001169155,0.0005693364,0.0005155751,0.0001737047,0.0003602443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9479441,0.00382282,0.01043561,0.00009166652,0.0004974697,0.00002975307,0.002790783,0.0002765869,0.02180316,0.000006699849,0.0000141759,0.01228715],"study_design_scores_gemma":[0.9356844,0.001034019,0.03099265,0.0003303827,0.0004394137,0.00007399386,0.0007418618,0.0004322843,0.02980961,0.00001068219,0.00001321038,0.0004374771],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986465,0.0005419126,0.00001192841,0.0002129673,0.001107462,0.01126295,0.00006955464,0.000124723,0.0002035098],"genre_scores_gemma":[0.9950882,0.001525046,0.00001812541,0.00005838574,0.001252163,0.001547535,0.0000518224,0.00008244745,0.0003763057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02055704,"threshold_uncertainty_score":0.9998285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150369800890378,"score_gpt":0.2894551881757657,"score_spread":0.2744182080867278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}