{"id":"W2983102880","doi":"10.7554/elife.49252.023","title":"Author response: Notch signalling maintains Hedgehog responsiveness via a Gli-dependent mechanism during spinal cord patterning in zebrafish","year":2019,"lang":"en","type":"peer-review","venue":"","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Notch signaling pathway; Zebrafish; Hedgehog signaling pathway; Spinal cord; Progenitor cell; Biology; Signalling; Hedgehog; Cell fate determination; Neuroscience; Cell biology; Transcription factor; Signal transduction; Stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009323099,0.0003098687,0.000308438,0.0007603127,0.0005598699,0.001022148,0.000625821,0.0005380946,0.03938006],"category_scores_gemma":[0.002526433,0.000156222,0.0001095477,0.0003889111,0.0005994453,0.0006634605,0.000842552,0.0003794388,0.01835839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009511716,"about_ca_system_score_gemma":0.001488031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003234349,"about_ca_topic_score_gemma":0.01046479,"domain_scores_codex":[0.9992747,0.00005340351,0.00003429965,0.00008694938,0.000497352,0.00005336955],"domain_scores_gemma":[0.9983088,0.0001286114,0.0001800345,0.000128845,0.00102776,0.0002259386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004011353,0.00004515833,0.004129777,0.0009665914,0.00003665294,0.001514236,0.0005880101,0.0006071756,0.6466981,0.007579081,0.08556937,0.2518648],"study_design_scores_gemma":[0.00003279394,0.00009108142,0.02142265,0.0001238139,0.0000331639,0.00091832,0.0003429399,0.0009415455,0.1243924,0.001221176,0.8504432,0.00003699421],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.4588857,0.02272065,0.03290173,0.02037591,0.01450526,0.0008090987,0.007459467,0.004776235,0.437566],"genre_scores_gemma":[0.3262761,0.005031425,0.005138785,0.0003378566,0.0007137562,0.0000588264,0.002024032,0.0006063303,0.659813],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.03938006,"threshold_uncertainty_score":0.1317394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03152719921358244,"score_gpt":0.3320775685706439,"score_spread":0.3005503693570614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}