{"id":"W2983137419","doi":"10.1182/blood-2019-129825","title":"Interim Analysis of a Prospective Multicentre Study Using Next Generation Sequencing for Kinase Domain Mutational Analysis in CML Patients on First or Subsequent TKI Therapy","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"","keywords":"Medicine; Ponatinib; Prospective cohort study; Internal medicine; Interim analysis; Oncology; Dasatinib; Clinical trial; Myeloid leukemia; Imatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0130307,0.0007314382,0.001302441,0.0005674809,0.0005323125,0.001171699,0.0006066157,0.0008886856,0.005546455],"category_scores_gemma":[0.01267415,0.0003408762,0.00265583,0.0007908974,0.0002846067,0.0006818553,0.0008448513,0.00122874,0.000691819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004584584,"about_ca_system_score_gemma":0.0008521991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006441145,"about_ca_topic_score_gemma":0.0006457727,"domain_scores_codex":[0.9925167,0.004160167,0.0004745406,0.001260625,0.0008255667,0.0007623358],"domain_scores_gemma":[0.9916934,0.003163995,0.001759891,0.001762365,0.0008449401,0.0007753724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0773293,0.001165488,0.871339,0.0008073495,0.008884051,0.0009879294,0.0004109848,0.002357057,0.004900069,0.0008836045,0.007522304,0.02341285],"study_design_scores_gemma":[0.002669916,0.0236423,0.9524134,0.0001026494,0.005637784,0.0008828377,0.0002163951,0.005119242,0.001748467,0.0008171696,0.006672817,0.00007705841],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719281,0.001894186,0.007571263,0.0004927306,0.0003372123,0.001637384,0.01266085,0.00009434804,0.003383951],"genre_scores_gemma":[0.9830363,0.0001964574,0.00450077,0.0004541106,0.000100932,0.002259939,0.007531567,0.00003144208,0.001888458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0130307,"threshold_uncertainty_score":0.06891382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06965957962405488,"score_gpt":0.3214276455862354,"score_spread":0.2517680659621805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}