{"id":"W2983139909","doi":"10.1113/jp278759","title":"Pannexin 1 activation and inhibition is permeant‐selective","year":2019,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"","keywords":"Pannexin; Biophysics; Chemistry; Permeation; Xenopus; Permeability (electromagnetism); Extracellular; Intracellular; Cell biology; Membrane; Biochemistry; Gap junction; Connexin; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003627127,0.000357469,0.0004741349,0.0001290976,0.0001364344,0.0005647573,0.0002904423,0.0003708474,0.002100422],"category_scores_gemma":[0.0003961507,0.000177685,0.0003908404,0.000141546,0.0003445762,0.0006635708,0.0003325462,0.000903774,0.0004190085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004017477,"about_ca_system_score_gemma":0.0002538609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002961231,"about_ca_topic_score_gemma":0.0003840828,"domain_scores_codex":[0.9994748,0.00006936799,0.00005781438,0.0001415504,0.0001557721,0.000100815],"domain_scores_gemma":[0.9997627,0.00008509923,0.00005659151,0.00003868052,0.00002535497,0.00003156236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006174998,0.00001911638,0.00005633069,0.00005196657,0.000004559326,0.00002163155,0.00001295313,0.00005680592,0.9987099,0.0001526857,0.00004269667,0.0008095491],"study_design_scores_gemma":[0.00001300075,0.0001190791,0.001268324,0.000005347062,0.000006748203,0.0001547469,0.00001417055,0.0005549579,0.9957144,0.00006398299,0.002081471,0.000003725937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800603,0.00298525,0.01072845,0.0003354482,0.0001182246,0.0001212886,0.0005018743,0.0003608908,0.00478829],"genre_scores_gemma":[0.9897019,0.001545017,0.004002371,0.0001738253,0.00002028128,0.0001160157,0.0004815242,0.0001017126,0.003857438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002100422,"threshold_uncertainty_score":0.007026553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006433802662074346,"score_gpt":0.2284290789032027,"score_spread":0.2219952762411284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}