{"id":"W2983257358","doi":"10.1182/blood-2019-123191","title":"Epigenomic Determinants of Transcriptional Activity in ASXL1-Mutant Chronic Myelomonocytic Leukemia","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"Epigenomics; Biology; H3K4me3; DNA methylation; Chromatin immunoprecipitation; Histone; Epigenetics; Wild type; Mutant; Enhancer; Genetics; Transcriptome; Cancer research; Molecular biology; Promoter; Transcription factor; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007921143,0.0001202016,0.0001425535,0.0003775782,0.00009926975,0.0002005625,0.00007355934,0.000137621,0.001288827],"category_scores_gemma":[0.0001282689,0.00006964227,0.00008541294,0.0002740146,0.0001351618,0.00009509599,0.0001694948,0.000128378,0.0001275154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001316455,"about_ca_system_score_gemma":0.00006119362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003451328,"about_ca_topic_score_gemma":0.0006193627,"domain_scores_codex":[0.9999309,0.000007955626,0.000004048622,0.00002638194,0.00001441763,0.0000163538],"domain_scores_gemma":[0.999903,0.00001685461,0.00004315763,0.000006056235,0.00001056518,0.0000203968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006227496,0.00001500308,0.06549965,0.00003807144,0.00002329727,0.0001006454,0.00007988892,0.0001511377,0.9296365,0.00004879698,0.00005980026,0.003724405],"study_design_scores_gemma":[0.00001564299,0.0002719924,0.9188265,0.000007480045,0.00005412856,0.001061579,0.0001621679,0.0007408393,0.07755471,0.0001102788,0.001187101,0.000007560088],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989542,0.0002089703,0.0002616976,0.00001106175,0.000001246742,0.000002861176,0.0004077964,0.000007587746,0.0001446834],"genre_scores_gemma":[0.9984296,0.0001283034,0.0003428344,0.00001948201,0.000002985581,0.00001132856,0.0007698375,0.000005162717,0.0002905721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001288827,"threshold_uncertainty_score":0.004311562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.018691820575642,"score_gpt":0.2847731354907214,"score_spread":0.2660813149150794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}