{"id":"W2983327530","doi":"10.1126/science.aaw4388","title":"Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility","year":2019,"lang":"en","type":"article","venue":"Science","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Nonribosomal peptide; Biosynthesis; Modular design; Enzyme; Peptide; Flexibility (engineering); Chemistry; Stereochemistry; Biochemistry; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000800206,0.0001992933,0.0002105355,0.000107744,0.0001618674,0.0003614479,0.000252421,0.0001841967,0.0009965849],"category_scores_gemma":[0.00016743,0.0001556761,0.000144212,0.0001723259,0.0002318782,0.0002487696,0.0002076127,0.0005653681,0.0001368717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004603344,"about_ca_system_score_gemma":0.0002424741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008715027,"about_ca_topic_score_gemma":0.0009219174,"domain_scores_codex":[0.9999559,0.000007127456,0.000002705739,0.00001289897,0.00001222547,0.000009109993],"domain_scores_gemma":[0.9999008,0.00001938695,0.00002708653,0.000009785966,0.00001374601,0.00002920597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004604727,0.00006353327,0.003831504,0.00009927073,0.00003830993,0.0006103525,0.000222332,0.008503824,0.9771661,0.003128033,0.0002899616,0.00558636],"study_design_scores_gemma":[0.0001640877,0.0008136372,0.02425544,0.0000332774,0.00009947101,0.00129866,0.0005302556,0.05434766,0.9016977,0.003016011,0.0136537,0.0000900844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970752,0.0002556834,0.00167021,0.00005917144,0.000004935312,0.000003447661,0.0001197278,0.00003485991,0.0007767698],"genre_scores_gemma":[0.9974044,0.0001215791,0.00178399,0.00002183859,0.000001425681,0.000002278359,0.0003120075,0.000008130517,0.0003443029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009965849,"threshold_uncertainty_score":0.003340006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01329442034614014,"score_gpt":0.2689944533723702,"score_spread":0.25570003302623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}