{"id":"W2983330076","doi":"10.1182/blood-2019-121870","title":"Immune Landscapes Predict Chemotherapy Resistance and Anti-Leukemic Activity of Flotetuzumab, an Investigational CD123×CD3 Bispecific Dart® Molecule, in Patients with Relapsed/Refractory Acute Myeloid Leukemia","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Immune system; Medicine; Interleukin-3 receptor; Immunotherapy; Chemotherapy regimen; Myeloid leukemia; Oncology; Leukemia; Immunology; Myeloid; Internal medicine; Chemotherapy; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002644965,0.0001751783,0.0002824964,0.0003903647,0.0001124756,0.0003054753,0.0001178893,0.0001947522,0.000629182],"category_scores_gemma":[0.0003618344,0.00009632132,0.0001342011,0.0002029388,0.0001613531,0.000143806,0.0001803625,0.0002530408,0.000137335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002058503,"about_ca_system_score_gemma":0.0000857284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003351814,"about_ca_topic_score_gemma":0.0005766236,"domain_scores_codex":[0.9998871,0.00002660669,0.000009600895,0.00003106599,0.00002509379,0.00002034882],"domain_scores_gemma":[0.9998503,0.00003818397,0.00005118006,0.000008063338,0.00001395422,0.00003836106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.00677812,0.0003806409,0.808844,0.00006109865,0.0001000604,0.0003063694,0.0001534048,0.001356277,0.1475482,0.00005808951,0.0004295845,0.03398421],"study_design_scores_gemma":[0.0001383275,0.002171711,0.9809717,0.000006463356,0.0000783151,0.00085678,0.00009093084,0.002932775,0.01193578,0.00007084234,0.0007404956,0.000005845848],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994583,0.0002627083,0.0000685413,0.00001336362,0.000001333443,0.000007136455,0.00005043475,0.000003221503,0.0001350009],"genre_scores_gemma":[0.9995172,0.00006267978,0.0001506475,0.00001905953,0.000003387064,0.000009824807,0.0001393348,9.6514e-7,0.00009689424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000629182,"threshold_uncertainty_score":0.002104819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006480575443973489,"score_gpt":0.2254982095047728,"score_spread":0.2190176340607994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}