{"id":"W2983378712","doi":"10.1038/s41598-019-52032-9","title":"Metabolic Activation of Flavin Monooxygenase-mediated Trimethylamine-N-Oxide Formation in Experimental Kidney Disease","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Division of Loan Repayment; National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; American College of Clinical Pharmacy Research Institute; American Foundation for Pharmaceutical Education; American Society of Nephrology; American College of Clinical Pharmacy; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Trimethylamine N-oxide; Monooxygenase; Trimethylamine; Kidney disease; Chemistry; Biochemistry; Enzyme; Flavin-containing monooxygenase; Internal medicine; Endocrinology; Biology; Medicine; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003504371,0.0003020154,0.0003018924,0.0003331212,0.0002114452,0.0002152827,0.0001395106,0.0003531283,0.0008387627],"category_scores_gemma":[0.0002296501,0.0001420541,0.0003087796,0.0001957618,0.0003382797,0.0002083697,0.0002301578,0.0005646209,0.000106444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003272834,"about_ca_system_score_gemma":0.0002713545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007076596,"about_ca_topic_score_gemma":0.001014822,"domain_scores_codex":[0.9998143,0.00006737383,0.00001414088,0.00002898724,0.00003826578,0.00003686714],"domain_scores_gemma":[0.9998329,0.00002102197,0.00005315396,0.00002468466,0.00001666372,0.0000515735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001858298,0.0002499548,0.002026773,0.0000994718,0.0000213241,0.00009701181,0.00003221818,0.00004339121,0.9932026,0.0001409984,0.00003729016,0.002190772],"study_design_scores_gemma":[0.0001912806,0.004533854,0.08406083,0.00003724698,0.0001116427,0.0006590465,0.0001152941,0.001419543,0.9064429,0.000295501,0.002115274,0.00001766097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937831,0.003171121,0.002184828,0.0001384724,0.00004524789,0.00003603216,0.0001006219,0.00002251932,0.000518074],"genre_scores_gemma":[0.9944249,0.001948689,0.002366392,0.00007130724,0.0000181704,0.00007258561,0.0001731163,0.000005527208,0.0009192848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008387627,"threshold_uncertainty_score":0.002805948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008832292353645126,"score_gpt":0.2603539086888366,"score_spread":0.2515216163351914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}