{"id":"W2983523128","doi":"10.1182/blood-2019-130255","title":"Whole Exome and Transcriptome Sequencing in 1042 Cases Reveals Distinct Clinically Relevant Genetic Subgroups of Follicular Lymphoma","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Follicular lymphoma; Chemoimmunotherapy; Biology; Germinal center; Oncology; Lymphoma; Exome sequencing; Rituximab; Internal medicine; Medicine; Genetics; Mutation; Gene; Immunology; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002703008,0.0002711595,0.0003315308,0.0007730345,0.0004341686,0.0005351247,0.0002556028,0.0005919486,0.001326437],"category_scores_gemma":[0.0008949404,0.0001794532,0.0003284036,0.0008657417,0.0003050062,0.0001753395,0.0005087672,0.0003067229,0.0004214525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002716592,"about_ca_system_score_gemma":0.0001614365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00199476,"about_ca_topic_score_gemma":0.003861421,"domain_scores_codex":[0.9996897,0.00003606121,0.00002990472,0.0001113343,0.00006724719,0.00006575409],"domain_scores_gemma":[0.9997705,0.00007559678,0.00003872623,0.00003388405,0.00004358868,0.00003770272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001435575,0.0001644236,0.7928226,0.0003133784,0.0003389152,0.01348536,0.001286915,0.000953396,0.1225898,0.0002671423,0.006411368,0.05993122],"study_design_scores_gemma":[0.00008521171,0.000177044,0.9664451,0.00005986845,0.0002115593,0.01459345,0.0007887984,0.00165176,0.005116217,0.0003181074,0.01052459,0.00002826478],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952094,0.0005238006,0.0006940001,0.00009291634,0.000007681566,0.00002351395,0.002852625,0.00002889906,0.0005672002],"genre_scores_gemma":[0.9859138,0.0003695426,0.001356509,0.0001745201,0.00002017876,0.00007807121,0.01138915,0.00002669936,0.0006714559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00199476,"threshold_uncertainty_score":0.004437387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01839609884378089,"score_gpt":0.2609930547105817,"score_spread":0.2425969558668008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}