{"id":"W2983657910","doi":"10.7554/elife.46134.028","title":"Author response: Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice","year":2019,"lang":"en","type":"peer-review","venue":"","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Institute for Advanced Research; University of Toronto","funders":"","keywords":"Frizzled; Wnt signaling pathway; Organoid; Cell biology; Biology; Chemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001499286,0.0002570577,0.0001959798,0.0004598671,0.0004136141,0.0009841467,0.0003549195,0.001633465,0.05756845],"category_scores_gemma":[0.003499244,0.0001556335,0.000188678,0.0001864208,0.000448193,0.0003531084,0.0007924284,0.001155687,0.01578102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000731049,"about_ca_system_score_gemma":0.000998605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006809799,"about_ca_topic_score_gemma":0.002636387,"domain_scores_codex":[0.9988735,0.0001529808,0.00005520813,0.0001597812,0.0006003623,0.0001580175],"domain_scores_gemma":[0.9976056,0.0004682525,0.0002719664,0.0001660448,0.001007918,0.0004803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005192027,0.00009462862,0.002040285,0.0005455866,0.00006110703,0.0006877617,0.0002916096,0.0002306231,0.2051996,0.008307227,0.6740448,0.1079775],"study_design_scores_gemma":[0.00006214112,0.0001032796,0.002589047,0.0000451147,0.00002164218,0.0005023928,0.0002099875,0.0001840336,0.04811797,0.001003631,0.9471416,0.00001912033],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"commentary","genre_scores_codex":[0.1358454,0.01559533,0.04437626,0.3116178,0.1313379,0.0009070066,0.003808056,0.00618633,0.3503259],"genre_scores_gemma":[0.1687537,0.005529422,0.01121966,0.03491794,0.005007542,0.0001932993,0.001458459,0.0006948677,0.7722252],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.05756845,"threshold_uncertainty_score":0.1925857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05789152022008846,"score_gpt":0.33559205911187,"score_spread":0.2777005388917815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}