{"id":"W2983677619","doi":"10.1182/blood-2019-122768","title":"Growth Factor-Dependent Activation of a MYC-Induced Latent AML Program in Human Hematopoietic Cells","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Terry Fox Research Institute; BC Cancer Agency","funders":"","keywords":"Biology; CD34; Haematopoiesis; Population; Bone marrow; Myeloid; Stem cell; Cancer research; Progenitor cell; Immunology; Transplantation; Molecular biology; CD38; Cell biology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001086713,0.0001288039,0.00008536669,0.0001560889,0.00007737191,0.0002394459,0.0001017055,0.0001081192,0.002578371],"category_scores_gemma":[0.00008571017,0.00005412292,0.0001318701,0.00009992384,0.0001080051,0.0001062054,0.0002193703,0.0004134672,0.0006608294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001754298,"about_ca_system_score_gemma":0.0001454859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000305653,"about_ca_topic_score_gemma":0.0004506449,"domain_scores_codex":[0.9999292,0.000009847415,0.000007627279,0.00001513311,0.00002237111,0.0000157751],"domain_scores_gemma":[0.9999009,0.0000203235,0.00002091924,0.00002173019,0.00001183312,0.00002422872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001400714,0.00004809423,0.0008013619,0.00002979403,0.000002959129,0.0000658749,0.00001869113,0.00003738523,0.9961928,0.0001858419,0.00008139741,0.002395682],"study_design_scores_gemma":[0.00005767576,0.0009050444,0.03241507,0.00001824255,0.00001525854,0.0009913594,0.00005438849,0.001847919,0.9549322,0.0001676842,0.008591007,0.000004188986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939182,0.001141128,0.002066999,0.0000720067,0.00001134947,0.00005234284,0.0006335613,0.0000994632,0.002004842],"genre_scores_gemma":[0.9957516,0.0002862183,0.001108987,0.00003625193,0.000006610347,0.0000431381,0.0009017101,0.00001125296,0.001854166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002578371,"threshold_uncertainty_score":0.008625507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02562509468783011,"score_gpt":0.3006790987588044,"score_spread":0.2750540040709744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}