{"id":"W2983697624","doi":"10.3390/cells8111462","title":"Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective","year":2019,"lang":"en","type":"review","venue":"Cells","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"False positive paradox; Computational biology; Protein kinase A; Competitive binding; Protein–protein interaction; Chemistry; Intracellular; Kinase; Biology; Biochemistry; Computer science; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006618854,0.0009269225,0.001109142,0.002016138,0.0002460059,0.0009537912,0.0007668918,0.001190177,0.003759634],"category_scores_gemma":[0.0007740128,0.0003097768,0.0005372746,0.001843596,0.0004411431,0.001446083,0.0007294105,0.002481599,0.002671965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006913975,"about_ca_system_score_gemma":0.0007818658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006365642,"about_ca_topic_score_gemma":0.001147935,"domain_scores_codex":[0.9998322,0.00002832698,0.00002377472,0.00003276424,0.0000601043,0.0000229679],"domain_scores_gemma":[0.9996566,0.0001815243,0.00003274677,0.00001217987,0.00008279472,0.00003410098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001270201,0.0001132997,0.0001356274,0.0192344,0.0000887267,0.0002391484,0.00006840586,0.0005894651,0.005044582,0.008898935,0.03628262,0.9291778],"study_design_scores_gemma":[0.00001229074,0.00009984051,0.000316195,0.001354396,0.00007126173,0.0005781974,0.000029396,0.00009130357,0.0007409299,0.001901723,0.9947908,0.0000137205],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001318698,0.9977379,0.0002153402,0.0004037983,0.0003262421,0.000004085468,0.00001940366,0.00001218821,0.00114928],"genre_scores_gemma":[0.0007348544,0.9976556,0.0002812869,0.0003214258,0.0002515503,0.000007125405,0.00003338147,0.000002507369,0.0007121947],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003759634,"threshold_uncertainty_score":0.01257718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02288119009473452,"score_gpt":0.3149297440055248,"score_spread":0.2920485539107902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}