{"id":"W2983697624","doi":"10.3390/cells8111462","title":"Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective","year":2019,"lang":"en","type":"review","venue":"Cells","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"False positive paradox; Computational biology; Protein kinase A; Competitive binding; Protein–protein interaction; Chemistry; Intracellular; Kinase; Biology; Biochemistry; Computer science; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001074875,0.0002903636,0.000638872,0.00008744379,0.00002518305,0.00001762578,0.0001808728,0.000294943,0.0001054037],"category_scores_gemma":[0.00002815695,0.0002385952,0.0002868334,0.0001998148,0.00005323375,0.000003598328,0.00006580172,0.0001810713,0.0001150456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007428439,"about_ca_system_score_gemma":0.0002206783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000233209,"about_ca_topic_score_gemma":0.000004057183,"domain_scores_codex":[0.9987419,0.0001459097,0.000271274,0.0005025084,0.0001099983,0.0002284586],"domain_scores_gemma":[0.9993423,0.00001741155,0.0001673699,0.0003475885,0.00007166185,0.00005368444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001603849,0.00007005522,2.629772e-7,0.001562603,0.00006243765,0.000005863237,0.00004470396,0.00001089034,0.005979434,0.0001506687,0.0001578895,0.9919391],"study_design_scores_gemma":[0.0001822541,0.00007150504,3.937115e-7,0.001269581,0.00005207656,0.000002859949,0.00004816768,0.000005568111,0.003871459,0.00005596777,0.9941502,0.000290007],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002533168,0.9978225,0.00006829804,0.00001746561,0.0002006771,0.0006554667,0.00004723948,0.000009981143,0.001153084],"genre_scores_gemma":[0.00005868282,0.9987089,0.0001240748,0.00004514622,0.0002558181,0.00005953428,0.0001614843,0.00004021035,0.000546157],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9939923,"threshold_uncertainty_score":0.9729632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02288119009473452,"score_gpt":0.3149297440055248,"score_spread":0.2920485539107902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}