{"id":"W2983745227","doi":"10.1182/blood-2019-126828","title":"Genetic and Transcript Changesin Cereblon in IMiD-Treated Myeloma Patients","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Cereblon; Pomalidomide; Lenalidomide; Multiple myeloma; Medicine; Oncology; Drug resistance; Cancer research; Internal medicine; Immunology; Biology; Genetics; Gene; Ubiquitin ligase; Ubiquitin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002100326,0.0001831111,0.0004130297,0.0009380124,0.0003685462,0.0005770824,0.0002204302,0.0003459822,0.002343545],"category_scores_gemma":[0.000541664,0.0001474936,0.0003219883,0.001112296,0.0002286527,0.000225238,0.0004054397,0.000489837,0.0003092121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004262828,"about_ca_system_score_gemma":0.0002103553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001584539,"about_ca_topic_score_gemma":0.002515271,"domain_scores_codex":[0.9997618,0.0000284806,0.00002467676,0.00007528682,0.00006817313,0.00004162415],"domain_scores_gemma":[0.9997,0.00005224061,0.0001221794,0.0000233402,0.00005949026,0.00004282737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002680273,0.0001454281,0.8519898,0.000602239,0.000426455,0.0041769,0.0008990166,0.0003795198,0.04209414,0.0002173438,0.004789502,0.0915994],"study_design_scores_gemma":[0.0000370958,0.0003220243,0.9725561,0.00009222853,0.0002684942,0.007197426,0.0005216175,0.0003263016,0.004810856,0.0003000014,0.01354292,0.00002497356],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816737,0.01039648,0.0004416177,0.0003368347,0.00004547234,0.0000380633,0.005019084,0.00004462703,0.002004042],"genre_scores_gemma":[0.9886762,0.004512221,0.001109322,0.0002908655,0.00006698743,0.00004057688,0.004008177,0.00002348611,0.001272301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002343545,"threshold_uncertainty_score":0.007839918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01427272949489228,"score_gpt":0.2478249857261943,"score_spread":0.233552256231302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}