{"id":"W2983764075","doi":"10.1074/mcp.ra119.001811","title":"Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion","year":2019,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Adherens junction; Cell biology; MAPK/ERK pathway; Ribosomal s6 kinase; Melanoma; Cell adhesion; Biology; Catenin; Cell growth; Protein kinase A; Kinase; Phosphorylation; Focal adhesion; Signal transduction; Cancer research; Cell; Cadherin; Wnt signaling pathway; PI3K/AKT/mTOR pathway; Biochemistry; P70-S6 Kinase 1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007057429,0.0003000254,0.0001802126,0.0003071855,0.0002223,0.0002393902,0.0001276008,0.0002553797,0.0009840741],"category_scores_gemma":[0.00009288312,0.0001203308,0.0003281807,0.0002104332,0.0001274834,0.0002303622,0.0001572955,0.0002712247,0.0004382181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001826623,"about_ca_system_score_gemma":0.0001347793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005444727,"about_ca_topic_score_gemma":0.0008680352,"domain_scores_codex":[0.9999369,0.000005335658,0.00000465749,0.00002109125,0.00001957067,0.00001238327],"domain_scores_gemma":[0.9999542,0.000004615625,0.00001510019,0.000003106012,0.000006452282,0.00001653196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000517403,0.000010422,0.0004292736,0.00002529482,0.000006054689,0.0000835781,0.000008619839,0.00002216791,0.9987349,0.00003877003,0.0000124244,0.0005767675],"study_design_scores_gemma":[0.00001798967,0.0002078321,0.110883,0.00001274718,0.00005300162,0.002046287,0.0001043904,0.002411287,0.8814338,0.0001779884,0.002635871,0.00001589735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995576,0.001569997,0.001626301,0.00006578748,0.00001015769,0.00001129911,0.0002404007,0.00002058221,0.000879321],"genre_scores_gemma":[0.9941761,0.001080429,0.002353015,0.00005266179,0.000008688105,0.00001246003,0.0007492481,0.000008251332,0.001559226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009840741,"threshold_uncertainty_score":0.003292024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003871656835783585,"score_gpt":0.2053250625571313,"score_spread":0.2014534057213478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}