{"id":"W2983767987","doi":"10.1182/blood-2019-122685","title":"Evaluating Luspatercept Responders in the Phase 3, Randomized, Double-Blind, Placebo-Controlled BELIEVE Trial of Luspatercept in Adult Beta-Thalassemia Patients (Pts) Who Require Regular Red Blood Cell (RBC) Transfusions","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Thalassemia; Beta thalassemia; Discontinuation; Randomization; Anemia; Ineffective erythropoiesis; Placebo; Population; Internal medicine; Erythropoiesis; Gastroenterology; Surgery; Randomized controlled trial; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001423431,0.001288423,0.002037707,0.0002632672,0.00033499,0.0009074321,0.0006537598,0.001507657,0.00619466],"category_scores_gemma":[0.00120184,0.0005099669,0.001343219,0.0002605583,0.0006260286,0.000840502,0.000254693,0.002852611,0.001112987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004667453,"about_ca_system_score_gemma":0.000778159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003472192,"about_ca_topic_score_gemma":0.001160575,"domain_scores_codex":[0.9996203,0.0001921506,0.00002358306,0.00006915112,0.00003096291,0.00006372238],"domain_scores_gemma":[0.9992937,0.0001781603,0.0002114462,0.00003912719,0.00005689688,0.0002206426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9636366,0.008289901,0.0008567814,0.0006381332,0.0007628846,0.00006672603,0.000061188,0.0003650079,0.005776476,0.0001090576,0.001353403,0.01808379],"study_design_scores_gemma":[0.8490815,0.1450652,0.002937428,0.0000425994,0.0004054249,0.00007897193,0.00002697861,0.0006832597,0.0006380395,0.0001562875,0.0008690011,0.00001527123],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982414,0.005654358,0.0008912133,0.00098117,0.0004420375,0.00524097,0.001171272,0.0002417661,0.002963305],"genre_scores_gemma":[0.9873784,0.001951461,0.001167116,0.001410944,0.0002834104,0.004282981,0.0009419693,0.00002541336,0.002558294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00619466,"threshold_uncertainty_score":0.02072316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02162328168054135,"score_gpt":0.305271933119544,"score_spread":0.2836486514390026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}