{"id":"W2983802169","doi":"10.1093/neuonc/noz175.381","title":"EXTH-50. THIOREDOXIN REDUCTASE1 AND MGMT SYNTHETIC LETHALITY ENHANCES CYTOTOXICITY OF PRIMA-1MET(APR-246) AND AURANOFIN IN GLIOBLASTOMA","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Auranofin; Temozolomide; Cancer research; DNA damage; Reactive oxygen species; Thioredoxin reductase; Thioredoxin; Cytotoxicity; Cell culture; Chemistry; Oxidative stress; Biology; Glioma; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001831756,0.0003846362,0.0004677548,0.0003114034,0.0001298364,0.0002318289,0.0002453087,0.0002887044,0.001618161],"category_scores_gemma":[0.0001337646,0.0001377276,0.0002373434,0.0002006243,0.0002300454,0.0001481209,0.0001878006,0.0005893821,0.0003155407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000195121,"about_ca_system_score_gemma":0.0002728155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000817447,"about_ca_topic_score_gemma":0.001090527,"domain_scores_codex":[0.9998555,0.00003915333,0.00001569134,0.00002009746,0.00002793874,0.00004160622],"domain_scores_gemma":[0.9998798,0.00001938917,0.00002176169,0.00001195234,0.00001079487,0.00005614232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001867089,0.0005596593,0.0003119992,0.00006269032,0.00001824958,0.00009014312,0.00002952787,0.0001283303,0.9936837,0.00007793541,0.0001356685,0.003035026],"study_design_scores_gemma":[0.0001939364,0.008353686,0.00504165,0.000007138084,0.00003201341,0.0002658685,0.00002765053,0.0008569938,0.9840487,0.00003056713,0.00113592,0.000005818216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978551,0.0007697266,0.0003510767,0.00007187868,0.00003472692,0.00003101977,0.0002109829,0.00005801776,0.0006174074],"genre_scores_gemma":[0.9969798,0.0004932287,0.0005864974,0.00004015156,0.00001323047,0.00004088748,0.0006171807,0.00000953323,0.001219533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001618161,"threshold_uncertainty_score":0.005413234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00810914141307381,"score_gpt":0.2717070347594999,"score_spread":0.2635978933464261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}