{"id":"W2983803118","doi":"10.1182/blood-2019-128302","title":"Impact of Tisagenlecleucel Chimeric Antigen Receptor (CAR)-T Cell Therapy Product Attributes on Clinical Outcomes in Adults with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (r/r DLBCL)","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; Hamilton Health Sciences","funders":"","keywords":"Chimeric antigen receptor; Diffuse large B-cell lymphoma; Medicine; Refractory (planetary science); Lymphoma; Cytokine release syndrome; Internal medicine; Oncology; Cancer research; Immunotherapy; Immunology; Biology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001497223,0.0002279387,0.0003159133,0.0002715784,0.00008761513,0.0005240054,0.0001761481,0.0002152025,0.001115814],"category_scores_gemma":[0.001769885,0.00006094187,0.000429972,0.0002420468,0.0001900446,0.0003352533,0.0001870701,0.0004021056,0.0001767325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002403856,"about_ca_system_score_gemma":0.0001576718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002166258,"about_ca_topic_score_gemma":0.0002944421,"domain_scores_codex":[0.9994141,0.0002399441,0.00005357523,0.00009606486,0.0001492762,0.00004696764],"domain_scores_gemma":[0.9983041,0.0006401562,0.0007365227,0.00007445926,0.0000954904,0.0001492484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05027685,0.001716936,0.8254176,0.0001755168,0.0007244929,0.0002266451,0.0001164938,0.002544832,0.01591278,0.00007109046,0.0005773275,0.1022395],"study_design_scores_gemma":[0.0006810607,0.03898787,0.9399131,0.00002651331,0.0006956132,0.0007953878,0.0001169734,0.005455918,0.01153332,0.0001254372,0.001653744,0.00001506694],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990076,0.0004633575,0.0001394945,0.00002425283,0.000002370719,0.00001338781,0.0001361445,0.000005213993,0.0002081098],"genre_scores_gemma":[0.9993737,0.00008469902,0.0001616294,0.00001961316,0.000004506603,0.000008938122,0.0002565249,0.000002157778,0.0000881558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001497223,"threshold_uncertainty_score":0.007918179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03243113997427867,"score_gpt":0.3346661829572612,"score_spread":0.3022350429829825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}