{"id":"W2983816200","doi":"10.1093/neuonc/noz175.183","title":"CSIG-12. PREX1 LINKS ABERRANT PI 3-KINASE PATHWAY SIGNALING TO MAINTENANCE OF THE NEURAL STEM CELL-LIKE PHENOTYPE OF GLIOBLASTOMA CELLS","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Ottawa Hospital","funders":"","keywords":"Neural stem cell; Biology; Cell biology; Stem cell; Progenitor cell; Cancer research; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001367005,0.0004269117,0.0004441699,0.0003430646,0.0002770524,0.0004806318,0.0003348297,0.0004671147,0.003806396],"category_scores_gemma":[0.0001278833,0.0002414033,0.0003046086,0.0002670229,0.0003081758,0.0001413791,0.0003764304,0.001135165,0.001998396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006094711,"about_ca_system_score_gemma":0.0005061947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002676201,"about_ca_topic_score_gemma":0.004214273,"domain_scores_codex":[0.9997953,0.00001397052,0.00001920683,0.00004707032,0.00007303455,0.0000514538],"domain_scores_gemma":[0.9998198,0.00001544147,0.00004930386,0.00002175288,0.0000172344,0.00007639536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001395618,0.00004417614,0.000402827,0.000051885,0.000007454944,0.0001019757,0.00001352266,0.0001339147,0.9973761,0.0001112258,0.0003406864,0.00127672],"study_design_scores_gemma":[0.00004393422,0.0002466315,0.02145627,0.00001412799,0.00002431706,0.0005102171,0.00006320262,0.003112975,0.9649943,0.0001195983,0.009401016,0.00001353612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819324,0.001481114,0.004104449,0.000431092,0.0001731554,0.00008832507,0.006639278,0.0007644434,0.004385815],"genre_scores_gemma":[0.9855436,0.0004813493,0.001583102,0.0002330487,0.000007815715,0.00006358669,0.005595349,0.0001219056,0.006370181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003806396,"threshold_uncertainty_score":0.01273364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009186315090915359,"score_gpt":0.2352039938448985,"score_spread":0.2260176787539831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}