{"id":"W2983824567","doi":"10.1182/blood-2019-125648","title":"The Identification of Novel Epigenetic Therapies for ALK-Driven Haematological Malignancies","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Anaplastic lymphoma kinase; Romidepsin; Anaplastic large-cell lymphoma; Cancer research; Context (archaeology); Brentuximab vedotin; Medicine; ALK inhibitor; Mitoxantrone; Panobinostat; Crizotinib; Lymphoma; Biology; Oncology; Internal medicine; Chemotherapy; Lung cancer; CD30","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002446444,0.0003389348,0.0003854563,0.0005487925,0.0001246247,0.0004450763,0.0002694645,0.0003170614,0.004782568],"category_scores_gemma":[0.0001593635,0.0001310457,0.0003135877,0.0002748564,0.0002148003,0.000264855,0.0003138034,0.0006091302,0.0007233308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004102904,"about_ca_system_score_gemma":0.0002908444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001785823,"about_ca_topic_score_gemma":0.0007849336,"domain_scores_codex":[0.9999084,0.00001500807,0.000006576281,0.0000195526,0.00003230938,0.0000181121],"domain_scores_gemma":[0.99994,0.00001307489,0.00001457041,0.000006367868,0.000013096,0.00001281216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004552756,0.0005797945,0.001586385,0.0007308454,0.00005190203,0.0003227021,0.00006111991,0.001320401,0.7910042,0.002943114,0.00174556,0.1991989],"study_design_scores_gemma":[0.0004508225,0.005948177,0.01015624,0.0001783746,0.0002234091,0.002236907,0.0001005757,0.003447341,0.861171,0.001248771,0.1148087,0.00002978682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8667423,0.07575952,0.02163184,0.002235716,0.0003259687,0.001165756,0.002743363,0.0006413134,0.02875425],"genre_scores_gemma":[0.9352052,0.03691585,0.0126354,0.0009272765,0.0001237166,0.0004527575,0.002310185,0.00004448716,0.01138512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004782568,"threshold_uncertainty_score":0.01599926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02101724006020656,"score_gpt":0.3118811343708165,"score_spread":0.2908638943106099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}