{"id":"W2983979814","doi":"10.1182/blood-2019-123652","title":"Dynamics of Activated CD8+ T-cells and Decreased Osteoclasts in the Tumor Microenvironment are Associated with Clinical Efficacy of Anti-PD-L1 and Anti-CD38 Combination Treatment in Relapsed or Refractory Multiple Myeloma","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"CD8; Cytotoxic T cell; CD38; Tumor microenvironment; Bone marrow; Daratumumab; Cancer research; Medicine; T cell; Internal medicine; Immunology; Multiple myeloma; Immune system; Oncology; Biology; CD34; Bortezomib; Stem cell; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000157971,0.0001383296,0.0003099325,0.000181396,0.0001022565,0.0002052853,0.0000862917,0.0001339943,0.001708459],"category_scores_gemma":[0.0002053416,0.00008449912,0.0001359152,0.0001155869,0.00008189191,0.00009339363,0.00008831362,0.0003398589,0.00020891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001880601,"about_ca_system_score_gemma":0.0001389817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003245881,"about_ca_topic_score_gemma":0.0005622599,"domain_scores_codex":[0.9999053,0.00001708161,0.000007581973,0.00002480104,0.00002547462,0.00001965694],"domain_scores_gemma":[0.999896,0.00001747553,0.00003382757,0.000007196003,0.000008623929,0.0000368058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.04988799,0.00281379,0.1768943,0.0003178683,0.0002957689,0.001035883,0.0002973547,0.001337697,0.6115685,0.0001102982,0.002881322,0.1525592],"study_design_scores_gemma":[0.001267035,0.02579316,0.9095221,0.00002951606,0.0002629345,0.001826585,0.0001012805,0.00173544,0.05306116,0.0001066794,0.006274786,0.00001930094],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983127,0.000702926,0.00009807808,0.00002291877,0.0000055484,0.00002152931,0.0002633122,0.00001514754,0.0005577893],"genre_scores_gemma":[0.9986917,0.0001602174,0.0001242455,0.00003154335,0.000007771719,0.00003355915,0.0004174723,0.000003108416,0.0005303962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001708459,"threshold_uncertainty_score":0.005715311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01942084070848164,"score_gpt":0.2802649628663222,"score_spread":0.2608441221578406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}