{"id":"W2984098544","doi":"10.3390/molecules24224090","title":"[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors","year":2019,"lang":"en","type":"article","venue":"Molecules","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; Technische Universität Braunschweig; Ministero dello Sviluppo Economico; Fonds Unique Interministériel; FP7 Food, Agriculture and Fisheries, Biotechnology; Deutsche Forschungsgemeinschaft; Ontario Ministry of Economic Development and Innovation; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Genome Canada; Fondation Jérôme Lejeune; Fundação de Amparo à Pesquisa do Estado de São Paulo; Diamond Light Source; European Commission; Pfizer","keywords":"DYRK1A; Chemistry; Kinase; IC50; Selectivity; Combinatorial chemistry; Pharmacology; Stereochemistry; Biochemistry; Biology; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001497571,0.0002560763,0.0002188674,0.000216794,0.00008523841,0.0001408077,0.0002482033,0.0002419863,0.0009525965],"category_scores_gemma":[0.00007736897,0.00009225858,0.0001778255,0.0001783391,0.0001434005,0.0001728062,0.0001377732,0.0003264395,0.0003420997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000182291,"about_ca_system_score_gemma":0.0001600237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004004135,"about_ca_topic_score_gemma":0.0009858509,"domain_scores_codex":[0.9999492,0.00001225129,0.000003352047,0.000007758578,0.00001167202,0.00001570696],"domain_scores_gemma":[0.999965,0.000004470603,0.00001020399,0.000002898548,0.000006821362,0.00001067191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003982401,0.0001503359,0.000195921,0.0003054205,0.00001684321,0.0003004169,0.00003745866,0.001366494,0.981325,0.001064465,0.0003069884,0.01453238],"study_design_scores_gemma":[0.0002475127,0.004015421,0.003643039,0.00005620328,0.00005673459,0.0007704459,0.00004253157,0.002881824,0.9579339,0.0003291734,0.02998506,0.0000381766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9476587,0.03096075,0.009264593,0.0002167216,0.0001068926,0.0002477707,0.00055121,0.0001807023,0.01081271],"genre_scores_gemma":[0.9790132,0.0107811,0.006839943,0.0001263992,0.00003112153,0.00006322424,0.00037397,0.00001597479,0.002754994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009525965,"threshold_uncertainty_score":0.003186762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004946773137438237,"score_gpt":0.2156951172063777,"score_spread":0.2107483440689394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}