{"id":"W2984121388","doi":"10.1053/j.gastro.2019.10.034","title":"Development and Validation of a Test to Monitor Endoscopic Activity in Patients With Crohn’s Disease Based on Serum Levels of Proteins","year":2019,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Mount Sinai Hospital","funders":"Pfizer Pharmaceuticals; University of California, San Diego; Allergan; Genentech; Merck Sharp and Dohme; Ferring; Crohn's and Colitis Foundation; Prometheus; Takeda Pharmaceuticals North America; Gilead Sciences; Mitsubishi Tanabe Pharma Corporation; Roche; Novo Nordisk; Janssen Biotech; Johnson and Johnson; Meso Scale Diagnostics; Teva Pharmaceutical Industries; Otsuka Pharmaceutical; Ferring Pharmaceuticals; Novartis; Boehringer Ingelheim; Amgen; Pfizer; Shire; Eli Lilly and Company; Takeda Pharmaceutical Company; AbbVie; Merck","keywords":"Medicine; Calprotectin; Cohort; Internal medicine; Confidence interval; Crohn's disease; Gastroenterology; Receiver operating characteristic; Faecal calprotectin; Immunology; Disease; Inflammatory bowel disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006372603,0.0001025657,0.0001239228,0.0000729334,0.00001024238,0.000002530874,0.00006771744,0.00003732938,0.00001096043],"category_scores_gemma":[0.00003693257,0.00009400805,0.00001658448,0.00002821242,0.00003180126,0.000004048823,0.00004949914,0.00003528387,0.0000019575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001782186,"about_ca_system_score_gemma":0.00005750575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002122841,"about_ca_topic_score_gemma":0.00002883373,"domain_scores_codex":[0.9993162,0.00005840254,0.0001462644,0.0002199464,0.0001002415,0.0001589203],"domain_scores_gemma":[0.9995618,0.000006269869,0.00009229974,0.0002036238,0.00005578443,0.00008016379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003498744,0.0003144145,0.9671878,0.00007949453,0.00001124901,0.000004687048,0.00002413723,0.00029794,0.02824224,7.229493e-7,0.000001661665,0.0003369704],"study_design_scores_gemma":[0.002145575,0.0009124824,0.9373909,0.00004167104,0.000005889804,6.802239e-8,0.000003828717,0.00002821369,0.05942098,5.592738e-7,0.000005736067,0.00004407726],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990023,6.833721e-7,0.0001731767,0.00002956898,0.00002645239,0.0006353222,0.0001221814,0.000002484412,0.000007809887],"genre_scores_gemma":[0.9989086,1.032445e-7,0.0009071217,0.00008669176,0.000007157159,0.00004917106,0.00002095291,0.00000991389,0.00001024345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03117875,"threshold_uncertainty_score":0.3833537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005395533913644338,"score_gpt":0.20719969020791,"score_spread":0.2018041562942657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}