{"id":"W2984121388","doi":"10.1053/j.gastro.2019.10.034","title":"Development and Validation of a Test to Monitor Endoscopic Activity in Patients With Crohn’s Disease Based on Serum Levels of Proteins","year":2019,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Mount Sinai Hospital","funders":"Pfizer Pharmaceuticals; University of California, San Diego; Allergan; Genentech; Merck Sharp and Dohme; Ferring; Crohn's and Colitis Foundation; Prometheus; Takeda Pharmaceuticals North America; Gilead Sciences; Mitsubishi Tanabe Pharma Corporation; Roche; Novo Nordisk; Janssen Biotech; Johnson and Johnson; Meso Scale Diagnostics; Teva Pharmaceutical Industries; Otsuka Pharmaceutical; Ferring Pharmaceuticals; Novartis; Boehringer Ingelheim; Amgen; Pfizer; Shire; Eli Lilly and Company; Takeda Pharmaceutical Company; AbbVie; Merck","keywords":"Medicine; Calprotectin; Cohort; Internal medicine; Confidence interval; Crohn's disease; Gastroenterology; Receiver operating characteristic; Faecal calprotectin; Immunology; Disease; Inflammatory bowel disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006196862,0.001471606,0.0009864024,0.002925877,0.0006432717,0.001678166,0.001018459,0.002182146,0.0007691929],"category_scores_gemma":[0.008856073,0.000503384,0.001178878,0.001101527,0.001215681,0.001113291,0.001016336,0.001800131,0.0008123926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006019036,"about_ca_system_score_gemma":0.0008650528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001049687,"about_ca_topic_score_gemma":0.0007508751,"domain_scores_codex":[0.9945925,0.001812362,0.0005352853,0.0009678761,0.001762426,0.0003295144],"domain_scores_gemma":[0.9920614,0.003307543,0.0008364831,0.0006279927,0.002650854,0.0005157336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003028498,0.00222523,0.8624263,0.000238906,0.0004217852,0.0003000733,0.0005012813,0.001218606,0.07522997,0.0004380916,0.001220966,0.05275039],"study_design_scores_gemma":[0.001055042,0.01685499,0.8346122,0.0002483668,0.0005882797,0.003378097,0.0007843128,0.02106616,0.110675,0.0007644255,0.009852575,0.0001206804],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9587044,0.002625159,0.028882,0.0009112586,0.0004784497,0.001374675,0.001315801,0.0004176301,0.005290697],"genre_scores_gemma":[0.970549,0.0003563971,0.0238031,0.0006708267,0.0001173894,0.0008320643,0.002293783,0.00005652831,0.001320798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006196862,"threshold_uncertainty_score":0.03277248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005395533913644338,"score_gpt":0.20719969020791,"score_spread":0.2018041562942657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}