{"id":"W2984122717","doi":"10.1182/blood-2019-123520","title":"Study Design of an Open-Label, Single-Arm, Multicenter, Phase 2 Study to Evaluate the Safety and Efficacy of Defibrotide in Adult Patients with Transplant-Associated Thrombotic Microangiopathy","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Defibrotide; Medicine; Thrombotic microangiopathy; Internal medicine; Calcineurin; Hepatic veno-occlusive disease; Eculizumab; Transplantation; Gastroenterology; Phases of clinical research; Surgery; Hematopoietic stem cell transplantation; Complement system; Immunology; Clinical trial; Immune system; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006501631,0.0002150361,0.0005673404,0.0001002832,0.00007566404,0.00001664313,0.000478424,0.00003878176,0.00004601525],"category_scores_gemma":[0.00009616712,0.0001475738,0.00002102057,0.0002049754,0.00005985464,0.00009560675,0.0001539874,0.00009258361,0.00001273234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002462718,"about_ca_system_score_gemma":0.00004240735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003415414,"about_ca_topic_score_gemma":0.000450503,"domain_scores_codex":[0.9971073,0.001518775,0.0006060961,0.0003900819,0.0001081693,0.0002695655],"domain_scores_gemma":[0.9987252,0.0003764403,0.0002204978,0.0004720946,0.0001758292,0.00002993171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008686746,0.1875301,0.7259588,0.00003657025,0.000803943,0.000005723889,0.008942943,0.0000469019,0.06775513,0.000002419672,0.000005247735,0.0002254156],"study_design_scores_gemma":[0.1529262,0.04426152,0.790552,0.0003117731,0.0008836367,0.000002584631,0.003903662,0.000007356468,0.006953172,0.000001184212,7.142289e-7,0.0001961769],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907008,0.0001176769,0.00001214569,0.000006709532,0.00007613692,0.008855548,0.0002035655,0.00001590533,0.00001155535],"genre_scores_gemma":[0.999756,0.000001970468,0.00005949305,0.00001663414,0.000001800206,0.00005798771,0.00007474093,0.00002200957,0.000009396445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1442394,"threshold_uncertainty_score":0.6017883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03255554137823226,"score_gpt":0.2948056112874015,"score_spread":0.2622500699091692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}