{"id":"W2984122717","doi":"10.1182/blood-2019-123520","title":"Study Design of an Open-Label, Single-Arm, Multicenter, Phase 2 Study to Evaluate the Safety and Efficacy of Defibrotide in Adult Patients with Transplant-Associated Thrombotic Microangiopathy","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Defibrotide; Medicine; Thrombotic microangiopathy; Internal medicine; Calcineurin; Hepatic veno-occlusive disease; Eculizumab; Transplantation; Gastroenterology; Phases of clinical research; Surgery; Hematopoietic stem cell transplantation; Complement system; Immunology; Clinical trial; Immune system; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01033031,0.003153089,0.003646711,0.0005637385,0.0008670837,0.001606828,0.001315068,0.00297869,0.008839744],"category_scores_gemma":[0.004874795,0.001094159,0.002077213,0.0005212009,0.001832188,0.002434628,0.0007932674,0.004480853,0.001809045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009919878,"about_ca_system_score_gemma":0.003430906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003906145,"about_ca_topic_score_gemma":0.000824971,"domain_scores_codex":[0.9965738,0.001943928,0.0002047943,0.0005904348,0.000230346,0.0004566899],"domain_scores_gemma":[0.9961271,0.0008028335,0.0008000613,0.0004541859,0.0004324893,0.001383455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8997675,0.07296117,0.004193401,0.0005529238,0.001123582,0.0001163036,0.0001235586,0.0006483176,0.005314912,0.0002300013,0.001199769,0.01376857],"study_design_scores_gemma":[0.5743142,0.4185641,0.003707994,0.0000371372,0.0004404738,0.0000613555,0.00004211822,0.000471321,0.0006253387,0.0002493454,0.001464349,0.00002224205],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9067224,0.00219066,0.00376912,0.001047874,0.0008271573,0.07825982,0.003083217,0.0001405529,0.003959268],"genre_scores_gemma":[0.8659682,0.001343842,0.0112128,0.003850737,0.001205248,0.10944,0.002743018,0.00005005371,0.004186123],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01033031,"threshold_uncertainty_score":0.05463254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03255554137823226,"score_gpt":0.2948056112874015,"score_spread":0.2622500699091692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}