{"id":"W2984168062","doi":"10.1038/s41586-019-1735-9","title":"An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp","year":2019,"lang":"en","type":"article","venue":"Nature","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":166,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Structural Genomics Consortium; Ontario Genomics; University of Toronto; McMaster University","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Bacteria; Biology; Effector; Cell envelope; Nucleotide; Metabolite; Pseudomonas aeruginosa; Cell biology; Microbiology; Biochemistry; Secretion; Adenosine; Escherichia coli; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002288813,0.0005905238,0.000263008,0.0002195586,0.0002020029,0.0003908385,0.0002865624,0.0003425156,0.001813794],"category_scores_gemma":[0.0002096831,0.0002038751,0.0003816816,0.0002077293,0.0002252073,0.0002605342,0.0003620341,0.0008280409,0.0008639934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004971286,"about_ca_system_score_gemma":0.000478243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00149482,"about_ca_topic_score_gemma":0.001596459,"domain_scores_codex":[0.9997656,0.00004074548,0.00001801264,0.00003985471,0.00006785879,0.00006802714],"domain_scores_gemma":[0.9998166,0.00005565889,0.00002839348,0.00003208173,0.00002736494,0.00003991875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008035898,0.00001925445,0.00007526074,0.00001130879,0.000001820802,0.00003142602,0.00000389835,0.00001706587,0.9992096,0.00005208757,0.00001592334,0.0004819063],"study_design_scores_gemma":[0.000005786656,0.0001376552,0.0009163871,0.0000012424,0.000003917984,0.00005620472,0.000007321984,0.0001528203,0.998237,0.00001463986,0.0004661079,8.979432e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800321,0.001641771,0.009573633,0.0001870755,0.0001220591,0.0000808233,0.0004814166,0.0001614392,0.007719668],"genre_scores_gemma":[0.985038,0.0008272994,0.004835121,0.0000964062,0.00002759775,0.00004537909,0.000930901,0.00005835221,0.008140893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001813794,"threshold_uncertainty_score":0.006067753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00264555392149158,"score_gpt":0.2353851030881184,"score_spread":0.2327395491666268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}