{"id":"W2984201945","doi":"10.1093/eurheartj/ehz807","title":"Pharmacodynamics, pharmacokinetics, and safety of single-dose subcutaneous administration of selatogrel, a novel P2Y12 receptor antagonist, in patients with chronic coronary syndromes","year":2019,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Antiplatelet Therapy and Cardiovascular Diseases","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Institutes of Health; Eisai; Idorsia Pharmaceuticals; British Heart Foundation; Osprey Medical; Daiichi-Sankyo; Medicines Company; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; CSL Behring; US WorldMeds; Ionis Pharmaceuticals; Abbott Vascular; Medicure; Gilead Sciences; Daiichi Sankyo Europe; Sanofi; ZonMw; Amgen; Pfizer","keywords":"Medicine; P2Y12; Pharmacodynamics; Pharmacokinetics; Placebo; Pharmacology; Antagonist; Platelet aggregation inhibitor; Platelet; Internal medicine; Anesthesia; Receptor; Platelet aggregation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003141707,0.0001566891,0.0003869038,0.0001102085,0.0000400264,0.00001270443,0.00006552256,0.00002969755,0.0002080563],"category_scores_gemma":[0.000009996897,0.000130905,0.0001293264,0.0001181549,0.0001150656,0.0001047363,0.00002568288,0.0002518053,0.000007595102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006550343,"about_ca_system_score_gemma":0.0001420337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001453352,"about_ca_topic_score_gemma":6.432945e-7,"domain_scores_codex":[0.9987158,0.0001565801,0.000414453,0.0001810048,0.0003445972,0.0001876072],"domain_scores_gemma":[0.9993523,0.0000318713,0.0002005474,0.0001516236,0.0001219935,0.0001416411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01564094,0.00146609,0.9101154,0.0003673068,0.0008217327,0.0005500808,0.0002254862,0.000313063,0.05780627,0.000008319644,0.0001294156,0.01255595],"study_design_scores_gemma":[0.01620145,0.005459245,0.9664236,0.000710465,0.0002468786,0.004803862,0.00005206198,0.0002013457,0.002236076,8.647394e-7,0.003462176,0.0002019127],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972169,0.00182591,0.00006961403,0.00005980163,0.0001347041,0.0003683691,0.00005053285,0.0000114844,0.0002627242],"genre_scores_gemma":[0.9984868,0.0009397979,0.000288894,0.00005518577,0.00008049923,3.931099e-7,0.0000455181,0.00003954312,0.00006339415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05630832,"threshold_uncertainty_score":0.533815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01332700713066531,"score_gpt":0.2480995130300835,"score_spread":0.2347725058994182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}