{"id":"W2984256470","doi":"10.1016/j.jsb.2019.107409","title":"Asparagine-84, a regulatory allosteric site residue, helps maintain the quaternary structure of Campylobacter jejuni dihydrodipicolinate synthase","year":2019,"lang":"en","type":"article","venue":"Journal of Structural Biology","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of Alberta; University of Lethbridge; University of Saskatchewan","funders":"","keywords":"Campylobacter jejuni; Allosteric regulation; Protein quaternary structure; Asparagine; Residue (chemistry); Biochemistry; Chemistry; Enzyme; Active site; Biology; Microbiology; Computational biology; Bacteria; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004209701,0.0002889548,0.0006045799,0.0001754533,0.0001002422,0.00004245887,0.0005917851,0.0002436554,0.001707911],"category_scores_gemma":[0.00008220407,0.0001582782,0.0001967535,0.0001904442,0.0002954979,0.0002966191,0.0001520794,0.0004424675,0.00002974121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008085011,"about_ca_system_score_gemma":0.00009042007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001440514,"about_ca_topic_score_gemma":0.00006097821,"domain_scores_codex":[0.9977834,0.0003820884,0.0008438261,0.0002932756,0.0002989654,0.0003984891],"domain_scores_gemma":[0.9978691,0.0001388182,0.001127334,0.0004799388,0.0002764061,0.0001083957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000593101,0.00000693784,0.02288144,0.00004545086,0.00005773706,0.00002192123,0.0003040514,0.0002348319,0.9741871,0.0009610982,0.0002009388,0.0005053661],"study_design_scores_gemma":[0.001743004,0.001499222,0.2587694,0.0001238322,0.0001489172,0.002089776,0.0002619764,0.0001386345,0.7164683,0.01706677,0.001252547,0.0004376388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956973,0.0005456004,0.00004871661,0.0004982229,0.002797475,0.0002090913,0.0001014932,0.00001555606,0.0000865933],"genre_scores_gemma":[0.9982356,0.00002100296,0.0006458684,0.0003557,0.0005723537,8.307792e-7,0.00001606529,0.00002023986,0.000132311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2577189,"threshold_uncertainty_score":0.9992046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005608662574163445,"score_gpt":0.231116290468905,"score_spread":0.2255076278947415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}