{"id":"W2984359187","doi":"10.1200/jco.19.02105","title":"Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair–Deficient Cancer: Results From the Phase II KEYNOTE-158 Study","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":2963,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Pembrolizumab; Medicine; Microsatellite instability; Cancer; Internal medicine; Oncology; Response Evaluation Criteria in Solid Tumors; Clinical endpoint; DNA mismatch repair; Phases of clinical research; Gastroenterology; Immunotherapy; Toxicity; Clinical trial; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001491236,0.0006421636,0.0008234309,0.0001581331,0.0002072132,0.0004895147,0.0003448504,0.0005255115,0.0009753078],"category_scores_gemma":[0.0009922014,0.0002327674,0.0006691741,0.0002078954,0.0002771729,0.0004067272,0.0001536068,0.001071732,0.000253982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005866957,"about_ca_system_score_gemma":0.0005892975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004218559,"about_ca_topic_score_gemma":0.0009456105,"domain_scores_codex":[0.9997638,0.0001162215,0.00002067229,0.00003847014,0.00002761287,0.00003323637],"domain_scores_gemma":[0.9994895,0.0001328644,0.0001460486,0.00003829803,0.00004078612,0.0001524094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.455592,0.0383581,0.1570368,0.00187362,0.003898946,0.0008690109,0.0007118505,0.004038215,0.1028622,0.0002966048,0.006485541,0.2279771],"study_design_scores_gemma":[0.2858892,0.3590974,0.3259356,0.0001945181,0.002919602,0.00209446,0.0002310361,0.004023002,0.01182658,0.0002004155,0.00753035,0.00005772445],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962708,0.002292935,0.000194565,0.0001335621,0.00001591249,0.0002316363,0.0003158303,0.00001567377,0.0005290848],"genre_scores_gemma":[0.9968818,0.001013188,0.0004691761,0.0002321452,0.00004001441,0.0001965891,0.0009180845,0.000005391615,0.0002435569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001491236,"threshold_uncertainty_score":0.007886469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05014804818147979,"score_gpt":0.4084384987829472,"score_spread":0.3582904506014675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}