{"id":"W2984367464","doi":"10.1542/peds.2019-2544","title":"Consider If You Will: Proton Pump Inhibitors in Children, Infections, and Precision Medicine","year":2019,"lang":"en","type":"letter","venue":"PEDIATRICS","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"Medicine; Omeprazole; CYP2C19; Proton-pump inhibitor; Confounding; Lansoprazole; Gastric acid; Internal medicine; Intensive care medicine; Pediatrics; Stomach; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004867082,0.0008442928,0.001456747,0.002172734,0.001890376,0.00400105,0.001867548,0.007513684,0.01241888],"category_scores_gemma":[0.03134872,0.0004404052,0.00088709,0.001315895,0.002534435,0.005932796,0.001806824,0.01078107,0.003023599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002031707,"about_ca_system_score_gemma":0.003917262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002567211,"about_ca_topic_score_gemma":0.008915347,"domain_scores_codex":[0.9954373,0.001491356,0.0004603111,0.0004812943,0.001801604,0.000328139],"domain_scores_gemma":[0.9788359,0.01168925,0.001605595,0.0005360432,0.004201273,0.003131884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007588435,0.0000516718,0.004949808,0.0004493095,0.00004624432,0.0004653496,0.000214902,0.00004454782,0.00005578705,0.002484504,0.9197433,0.07141867],"study_design_scores_gemma":[0.0001002006,0.0002047824,0.009893812,0.002773365,0.0001335149,0.003791395,0.001363459,0.0002191721,0.0001892923,0.0100274,0.9712337,0.00006984946],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001311925,0.0737883,0.0007134956,0.7995533,0.1169243,0.00005350263,0.0002550241,0.0001286287,0.007271498],"genre_scores_gemma":[0.01609529,0.09945431,0.001714209,0.4443573,0.4282315,0.000110117,0.0002366063,0.00009758594,0.00970311],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01241888,"threshold_uncertainty_score":0.04154533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03111900818247772,"score_gpt":0.3393198265328617,"score_spread":0.308200818350384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}