{"id":"W2984412925","doi":"10.1371/journal.pone.0221288","title":"Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute; Bijzonder Onderzoeksfonds UGent; National Institutes of Health; William Lawrence and Blanche Hughes Foundation; Vlaamse regering; Universiteit Gent; Stand Up To Cancer; Fonds Wetenschappelijk Onderzoek; Children’s Oncology Group; AstraZeneca; European Hematology Association; Boston Children's Hospital; Children's Hospital of Philadelphia","keywords":"Haploinsufficiency; Fanconi anemia; Biology; Cancer research; Genetics; Point mutation; Mutation; Germline mutation; DNA repair; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002109178,0.0002909937,0.0006406329,0.0004104506,0.00006413699,0.00003884171,0.0002725649,0.0002239769,0.001028935],"category_scores_gemma":[0.0002700914,0.0002717715,0.0001100833,0.0007042124,0.00009997404,0.000176398,0.0001503303,0.0004945191,0.004869848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002337539,"about_ca_system_score_gemma":0.002665071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001083378,"about_ca_topic_score_gemma":0.0000219713,"domain_scores_codex":[0.9971265,0.00007107134,0.000488394,0.000584003,0.0009886043,0.0007413787],"domain_scores_gemma":[0.9982957,0.0003764778,0.0001061414,0.0007109132,0.000186012,0.0003247313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001303294,0.01620436,0.1093917,0.001990892,0.002516194,0.002006887,0.004838528,0.0003511149,0.8548434,0.001070809,0.002314558,0.003168228],"study_design_scores_gemma":[0.07820271,0.004544193,0.2324248,0.004408482,0.001970959,0.0004483167,0.001317157,0.05493413,0.6171989,0.001527718,0.0009282405,0.002094408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741947,0.0001474419,0.00008086694,0.0004208521,0.00007768307,0.001285789,0.00005182111,0.000143522,0.02359734],"genre_scores_gemma":[0.9868643,0.00008599412,0.00250179,0.0005547237,0.0001693135,0.0001280377,0.0001383504,0.00008887985,0.00946858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2376445,"threshold_uncertainty_score":0.9999735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01626759392150492,"score_gpt":0.2360025417590519,"score_spread":0.219734947837547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}