{"id":"W2984412925","doi":"10.1371/journal.pone.0221288","title":"Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute; Bijzonder Onderzoeksfonds UGent; National Institutes of Health; William Lawrence and Blanche Hughes Foundation; Vlaamse regering; Universiteit Gent; Stand Up To Cancer; Fonds Wetenschappelijk Onderzoek; Children’s Oncology Group; AstraZeneca; European Hematology Association; Boston Children's Hospital; Children's Hospital of Philadelphia","keywords":"Haploinsufficiency; Fanconi anemia; Biology; Cancer research; Genetics; Point mutation; Mutation; Germline mutation; DNA repair; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002138843,0.0002502275,0.0002085013,0.001135996,0.0003008647,0.0002618665,0.0001382164,0.0002707186,0.0008556772],"category_scores_gemma":[0.0003065396,0.0001373777,0.0001136977,0.0009535422,0.0003464509,0.0001144534,0.0002341066,0.0001589375,0.0001503275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004050307,"about_ca_system_score_gemma":0.0003117801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00211393,"about_ca_topic_score_gemma":0.002575032,"domain_scores_codex":[0.9998446,0.00003628601,0.00001788788,0.00003054458,0.00003691554,0.00003371935],"domain_scores_gemma":[0.9998834,0.00003173184,0.00004090611,0.00000901508,0.000008772198,0.00002615919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002609001,0.0001099708,0.4026495,0.0004937667,0.00008001981,0.03539151,0.0005739085,0.001609336,0.4969317,0.001102398,0.001111228,0.05733767],"study_design_scores_gemma":[0.0001161949,0.0004937327,0.7817502,0.00005430306,0.0001919038,0.1042128,0.0004208687,0.001500823,0.1008275,0.0007308969,0.009679441,0.00002130056],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963549,0.00190226,0.0004155612,0.00003938294,0.000005212958,0.00002601274,0.0002551191,0.00003272245,0.000968751],"genre_scores_gemma":[0.998502,0.0007842029,0.0003723921,0.00001214749,0.000003627264,0.000007874156,0.0001716656,0.000003942302,0.0001421312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00211393,"threshold_uncertainty_score":0.00420326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01626759392150492,"score_gpt":0.2360025417590519,"score_spread":0.219734947837547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}