{"id":"W2984431814","doi":"10.1093/jncics/pkz093","title":"Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors","year":2019,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":207,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; National Institutes of Health; GlaxoSmithKline","keywords":"Bromodomain; Medicine; Nut; Cancer research; Internal medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001065549,0.0009387463,0.001323024,0.0003080971,0.0002662237,0.0005465148,0.0005404889,0.0006182507,0.00214183],"category_scores_gemma":[0.0004832575,0.0004181028,0.0007026932,0.0002397138,0.0004384305,0.0004901902,0.0002372343,0.001528278,0.0004356914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007215521,"about_ca_system_score_gemma":0.001178541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009418497,"about_ca_topic_score_gemma":0.002781135,"domain_scores_codex":[0.9997033,0.0001370436,0.00001647759,0.00005989162,0.00003423428,0.00004908205],"domain_scores_gemma":[0.999597,0.00006060104,0.00009339026,0.00003825265,0.00003513475,0.0001755979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3806081,0.09168784,0.01900738,0.001207013,0.001519341,0.0006328506,0.0005055937,0.006273718,0.3617728,0.0004490143,0.005467957,0.1308684],"study_design_scores_gemma":[0.1887728,0.7442897,0.02181416,0.0000286469,0.0006102854,0.0007297819,0.00007250774,0.003240479,0.0356748,0.0001953602,0.004537352,0.0000340798],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946997,0.001333409,0.0006622734,0.0001396737,0.00003614935,0.001463583,0.0007615096,0.0000799602,0.0008237251],"genre_scores_gemma":[0.9924098,0.0009828135,0.001702344,0.000285671,0.0000444775,0.001183997,0.001629269,0.00002572459,0.001735843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00214183,"threshold_uncertainty_score":0.007165134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009424531050998724,"score_gpt":0.2753434312589721,"score_spread":0.2659189002079734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}