{"id":"W2984504359","doi":"10.1128/msystems.00465-19","title":"Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria","year":2019,"lang":"en","type":"article","venue":"mSystems","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Biology; Mutagenesis; Microbiology; Genetics; Gene; Escherichia coli; Klebsiella pneumoniae; Whole genome sequencing; Bacteria; Pseudomonas aeruginosa; Antibiotic resistance; Imipenem; Enterobacteriaceae; Bacterial outer membrane; Genome; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002673582,0.0001766644,0.0002678598,0.00003931635,0.00003311009,0.00003976531,0.0002666617,0.0001674496,0.00002876931],"category_scores_gemma":[0.0000614208,0.0001741103,0.00008801656,0.00007806064,0.00004301044,0.000005194282,0.00005758511,0.00005432052,0.00006170488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005511571,"about_ca_system_score_gemma":0.00005509021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005244437,"about_ca_topic_score_gemma":0.0005424838,"domain_scores_codex":[0.9987623,0.00005561496,0.0003218233,0.000457691,0.00008806733,0.0003145092],"domain_scores_gemma":[0.9992283,0.00002856929,0.0001445187,0.000488228,0.00005950587,0.00005085675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004507513,0.00002616321,0.03098623,0.0001574153,0.00003558846,0.000001568806,0.00006198724,0.000005394437,0.9661461,0.000354356,0.001699236,0.00007525726],"study_design_scores_gemma":[0.004595286,0.00040053,0.2045999,0.0004554167,0.00002488977,0.00001048835,0.0005304534,0.00009231136,0.6021615,0.0004208677,0.1856678,0.001040579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993655,0.0003045604,0.000242735,0.00005916881,0.0004173251,0.0009186903,0.00009040701,0.00001228268,0.004299815],"genre_scores_gemma":[0.9898115,0.00002221333,0.002478437,0.00006521803,0.0002277171,0.00003806471,0.0001382383,0.00003910879,0.007179436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3639846,"threshold_uncertainty_score":0.7100011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00863451842465147,"score_gpt":0.2374893263768976,"score_spread":0.2288548079522461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}