{"id":"W2984504359","doi":"10.1128/msystems.00465-19","title":"Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria","year":2019,"lang":"en","type":"article","venue":"mSystems","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Biology; Mutagenesis; Microbiology; Genetics; Gene; Escherichia coli; Klebsiella pneumoniae; Whole genome sequencing; Bacteria; Pseudomonas aeruginosa; Antibiotic resistance; Imipenem; Enterobacteriaceae; Bacterial outer membrane; Genome; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002346657,0.0005327614,0.0005583881,0.0007424534,0.0002991123,0.0003065375,0.0002817307,0.0003952459,0.001624109],"category_scores_gemma":[0.000356588,0.000159533,0.0003647079,0.0006289941,0.0001532567,0.000190083,0.0003805212,0.0003483607,0.0006106721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002539822,"about_ca_system_score_gemma":0.0002484775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000451619,"about_ca_topic_score_gemma":0.001352213,"domain_scores_codex":[0.9996623,0.00005064766,0.00002337701,0.00007829335,0.000142448,0.00004301043],"domain_scores_gemma":[0.9997954,0.000050907,0.0000465081,0.00002347521,0.00005509553,0.00002870499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002720573,0.00002861488,0.0004020032,0.00004132951,0.000006455153,0.00003609678,0.000008688959,0.00004519293,0.9976418,0.00002439215,0.00006114878,0.001677166],"study_design_scores_gemma":[0.00000895539,0.0006128536,0.01651827,0.00001029278,0.00005734448,0.000303684,0.00007822357,0.001089824,0.9770249,0.00006872084,0.004213307,0.00001363636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9481581,0.002254318,0.02921094,0.0005344353,0.0001038552,0.0005369257,0.01196499,0.001063994,0.006172465],"genre_scores_gemma":[0.9374108,0.002166512,0.03924381,0.0006564886,0.00003516175,0.0004516846,0.01158675,0.0002525104,0.008196289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001624109,"threshold_uncertainty_score":0.005433202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00863451842465147,"score_gpt":0.2374893263768976,"score_spread":0.2288548079522461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}