{"id":"W2984545918","doi":"10.1182/blood-2019-128604","title":"A Phase 2 Study of MT-3724 to Evaluate Safety, Pharmacodynamics and Efficacy of MT-3724 for the Treatment of Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Immunotoxin; Medicine; Lymphoma; Diffuse large B-cell lymphoma; CD20; Refractory (planetary science); Population; Aggressive lymphoma; Cytotoxic T cell; Internal medicine; Oncology; Cancer research; Immunology; Antibody; Rituximab; Biology; Monoclonal antibody; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002179896,0.0002452443,0.0005484389,0.00009569855,0.00009966941,0.000004740868,0.0002172001,0.0001143061,0.0001019092],"category_scores_gemma":[0.00003114529,0.0001403754,0.00009811818,0.0001288872,0.00006470495,0.00004749317,0.0000719167,0.00006338504,0.000009847245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003140495,"about_ca_system_score_gemma":0.00007542975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005055927,"about_ca_topic_score_gemma":0.00003044323,"domain_scores_codex":[0.9986697,0.0001543383,0.0004881312,0.0003154802,0.00008761913,0.000284741],"domain_scores_gemma":[0.9985527,0.0003916858,0.0003588841,0.0005230156,0.0001454469,0.00002828819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.02537225,0.3479194,0.0037482,0.0001129976,0.002150899,0.000002386168,0.007325592,0.000007448885,0.5999615,0.00004558118,0.00003172114,0.01332204],"study_design_scores_gemma":[0.6120481,0.1265405,0.01640413,0.00008607251,0.002358161,0.000004316391,0.002073962,0.00008877595,0.2339877,0.000007613732,0.006037856,0.0003627742],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947936,0.0008678116,0.00009471565,0.0000110656,0.0002499824,0.003285564,0.0006554551,0.00001449925,0.00002729322],"genre_scores_gemma":[0.998637,0.0002380155,0.0001271592,0.00002310602,0.000008236846,0.00009222436,0.00008290659,0.00003387533,0.0007575057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5866759,"threshold_uncertainty_score":0.5724342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01043908354557151,"score_gpt":0.2663643661985521,"score_spread":0.2559252826529806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}