{"id":"W2984545918","doi":"10.1182/blood-2019-128604","title":"A Phase 2 Study of MT-3724 to Evaluate Safety, Pharmacodynamics and Efficacy of MT-3724 for the Treatment of Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Immunotoxin; Medicine; Lymphoma; Diffuse large B-cell lymphoma; CD20; Refractory (planetary science); Population; Aggressive lymphoma; Cytotoxic T cell; Internal medicine; Oncology; Cancer research; Immunology; Antibody; Rituximab; Biology; Monoclonal antibody; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006009706,0.0009152862,0.001312915,0.0003396792,0.0002916966,0.0006856805,0.0006122231,0.0009608041,0.005203206],"category_scores_gemma":[0.0003816923,0.0004275381,0.0009830554,0.0002925344,0.0005843382,0.0004580579,0.0002404342,0.002255292,0.0009560875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007933464,"about_ca_system_score_gemma":0.001170524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001127186,"about_ca_topic_score_gemma":0.002344996,"domain_scores_codex":[0.9998517,0.00004603694,0.000006060772,0.00003367865,0.00002203209,0.00004040671],"domain_scores_gemma":[0.9997665,0.00002565263,0.00003930367,0.00002715329,0.00002428103,0.0001169844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3858309,0.1408481,0.005349954,0.00176691,0.001936975,0.001031731,0.0006030065,0.006352433,0.2526357,0.001275415,0.008007913,0.194361],"study_design_scores_gemma":[0.1941683,0.7723197,0.006244723,0.0000647241,0.0004969908,0.0008076209,0.00009488284,0.001873124,0.0155513,0.0004859162,0.007856184,0.00003666561],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912589,0.002401936,0.0008990047,0.0004036394,0.0001113408,0.002166456,0.001032565,0.0001016707,0.0016244],"genre_scores_gemma":[0.9873391,0.001976881,0.001707234,0.0005762209,0.00008157321,0.002002238,0.00182194,0.00003258815,0.00446227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005203206,"threshold_uncertainty_score":0.01740652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01043908354557151,"score_gpt":0.2663643661985521,"score_spread":0.2559252826529806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}