{"id":"W2984561122","doi":"10.1093/neuonc/noz175.298","title":"DRES-10. TEMOZOLOMIDE-ASSOCIATED HYPERMUTATION DETECTED WITH A GENE PANEL SIGNATURE IMPROVES IMMUNE RESPONSE IN GLIOBLASTOMA","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Somatic hypermutation; Temozolomide; Microsatellite instability; Cancer research; Gene signature; Biology; Gene; Concordance; Medicine; Glioblastoma; Oncology; Genetics; Gene expression; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000289014,0.0002086772,0.000393437,0.0003366248,0.0001055415,0.0003193695,0.0001451099,0.0001291512,0.001188132],"category_scores_gemma":[0.0003578141,0.00007061886,0.0002309322,0.0002832845,0.0000947485,0.0001135434,0.0001569259,0.0003610211,0.0002148007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003094524,"about_ca_system_score_gemma":0.0002540108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00142162,"about_ca_topic_score_gemma":0.002979702,"domain_scores_codex":[0.9998789,0.00001480223,0.0000103804,0.000040591,0.00002888342,0.00002652441],"domain_scores_gemma":[0.9998572,0.00002149037,0.00004098794,0.00001335564,0.00003009534,0.00003688681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005739917,0.0008455734,0.108687,0.0004208875,0.0004001144,0.0001912313,0.00007567468,0.003549068,0.7919175,0.000151864,0.005629552,0.08239158],"study_design_scores_gemma":[0.0003289142,0.005911505,0.611634,0.00007315107,0.0006184652,0.001098717,0.000218456,0.01827825,0.346797,0.0004778796,0.01451504,0.00004857341],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935783,0.000678434,0.0006162725,0.00008608589,0.00002306258,0.00002586627,0.004362236,0.00009996619,0.0005297287],"genre_scores_gemma":[0.9857337,0.0003641666,0.00132841,0.0001564732,0.000007907417,0.00003889518,0.01173665,0.00001899974,0.0006148134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00142162,"threshold_uncertainty_score":0.003974676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006310535102696933,"score_gpt":0.2301375411185158,"score_spread":0.2238270060158188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}