{"id":"W2984573171","doi":"10.1182/blood.v128.22.1386.1386","title":"Development of Platforms to Phenotype Variants of Uncertain Significance in VWF","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"","keywords":"Von Willebrand disease; Von Willebrand factor; Phage display; Mutant; Peptide library; Genetics; Biology; Molecular biology; Platelet; Point mutation; DNA; Chemistry; Mutation; Gene; Peptide sequence; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001090146,0.0007107286,0.0007318237,0.0007749574,0.0003368285,0.001167932,0.00125824,0.001030337,0.005248196],"category_scores_gemma":[0.001780716,0.0005034757,0.0006738144,0.0004441153,0.0003520125,0.000784924,0.001565127,0.001470213,0.003858286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004219979,"about_ca_system_score_gemma":0.0003115887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005386208,"about_ca_topic_score_gemma":0.0007006347,"domain_scores_codex":[0.9992359,0.0001052179,0.00005184342,0.0001980104,0.0002759026,0.0001332075],"domain_scores_gemma":[0.9991918,0.0001996847,0.000156802,0.0001372794,0.0001545966,0.0001598404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001307251,0.0001172074,0.0007331156,0.00008339957,0.00002413611,0.0002207658,0.00005205039,0.0004314317,0.9800686,0.0008462519,0.0009206627,0.01637155],"study_design_scores_gemma":[0.00006316234,0.0005893448,0.00286599,0.00004499679,0.00009437073,0.001009868,0.00010371,0.009844226,0.9544683,0.0009246343,0.02992946,0.00006200297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.561394,0.002255396,0.4026466,0.001306733,0.0005648865,0.002308168,0.005348226,0.01273791,0.01143805],"genre_scores_gemma":[0.6112814,0.002091678,0.3519121,0.001132202,0.00009834763,0.002288825,0.00938702,0.002646625,0.01916176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005248196,"threshold_uncertainty_score":0.01755697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02189263673024712,"score_gpt":0.26285408144977,"score_spread":0.2409614447195229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}