{"id":"W2984712394","doi":"10.1016/s1470-2045(19)30688-6","title":"Optimal sequencing of enzalutamide and abiraterone acetate plus prednisone in metastatic castration-resistant prostate cancer: a multicentre, randomised, open-label, phase 2, crossover trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":352,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; Spinal Cord Injury BC; Kelowna General Hospital","funders":"","keywords":"Enzalutamide; Abiraterone acetate; Prostate cancer; Medicine; Prednisone; Open label; Oncology; Internal medicine; Abiraterone; Randomized controlled trial; Crossover study; Docetaxel; Cancer; Androgen deprivation therapy; Placebo; Androgen receptor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002151905,0.002646819,0.004001382,0.0005902,0.0004513672,0.001459502,0.0009810934,0.001767269,0.006711212],"category_scores_gemma":[0.002680253,0.001108344,0.001951193,0.0004986274,0.001805518,0.001748184,0.0005942145,0.003878473,0.001179794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001111978,"about_ca_system_score_gemma":0.001404583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00166326,"about_ca_topic_score_gemma":0.002525352,"domain_scores_codex":[0.9988152,0.0006589665,0.00007059649,0.0002276398,0.00007697551,0.0001506896],"domain_scores_gemma":[0.9986369,0.0004657005,0.0002789284,0.0001207838,0.00006922079,0.0004284689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9886137,0.002525431,0.0001388581,0.0002087708,0.0004987487,0.00001090732,0.00004156583,0.0004223404,0.0006984394,0.00006650492,0.0001970697,0.006577728],"study_design_scores_gemma":[0.9604628,0.03782728,0.0005112762,0.00002170889,0.0002525234,0.00001494903,0.00001552278,0.0003842528,0.0001089594,0.0001857445,0.0002003839,0.00001450617],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898157,0.003940713,0.0009792644,0.0005337127,0.0006981921,0.001990191,0.0004568718,0.0001507394,0.001434562],"genre_scores_gemma":[0.991276,0.001914005,0.001689434,0.0005740701,0.0003628482,0.001936884,0.0004145055,0.00003587179,0.001796448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006711212,"threshold_uncertainty_score":0.02245122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1205059099112498,"score_gpt":0.4350927641428153,"score_spread":0.3145868542315654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}