{"id":"W2984712394","doi":"10.1016/s1470-2045(19)30688-6","title":"Optimal sequencing of enzalutamide and abiraterone acetate plus prednisone in metastatic castration-resistant prostate cancer: a multicentre, randomised, open-label, phase 2, crossover trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":352,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; Spinal Cord Injury BC; Kelowna General Hospital","funders":"","keywords":"Enzalutamide; Abiraterone acetate; Prostate cancer; Medicine; Prednisone; Open label; Oncology; Internal medicine; Abiraterone; Randomized controlled trial; Crossover study; Docetaxel; Cancer; Androgen deprivation therapy; Placebo; Androgen receptor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001213273,0.0002057985,0.001169393,0.00009263941,0.00007777529,0.00005400053,0.0002204438,0.00007414512,0.0001324948],"category_scores_gemma":[0.000100854,0.0001278439,0.00003911811,0.0002152021,0.0002795868,0.0001857679,0.0001493777,0.0003087126,0.00001055888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006514315,"about_ca_system_score_gemma":0.00141965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001270295,"about_ca_topic_score_gemma":0.0007277565,"domain_scores_codex":[0.9978944,0.0003872018,0.0005748714,0.0003593953,0.0002512757,0.0005328497],"domain_scores_gemma":[0.99876,0.0003923447,0.0002907703,0.0003317654,0.0001152864,0.0001098002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8570954,0.0007265379,0.0006203942,0.0003555992,0.0003727158,0.0002282558,0.005312047,0.0006219709,0.1307544,0.00007389422,0.0001527058,0.003686076],"study_design_scores_gemma":[0.9748497,0.005044343,0.0005623537,0.0002194797,0.0002776983,0.00003998911,0.00103087,0.005583844,0.01109606,0.0000716467,0.001068346,0.0001556929],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882034,0.002408635,0.000007060066,0.00189191,0.0001821243,0.00656575,0.0001381018,0.00001687084,0.0005861141],"genre_scores_gemma":[0.9934527,0.002168076,0.001378401,0.0002283318,0.0001092881,0.0006488142,0.00004325965,0.00002589731,0.001945285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1196584,"threshold_uncertainty_score":0.5213324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1205059099112498,"score_gpt":0.4350927641428153,"score_spread":0.3145868542315654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}