{"id":"W2984737845","doi":"10.1093/neuonc/noz175.436","title":"GENE-34. THERAPEUTICALLY TARGETING EPIGENOMIC AND TRANSCRIPTIONAL DYSFUNCTION IN ATRX-DEFICIENT GLIOMA","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"ATRX; SIRT2; Epigenomics; Biology; Chromatin; Death-associated protein 6; Epigenetics; Genetics; Histone; Gene; Cancer research; Mutation; DNA methylation; Gene expression; Sirtuin; Nuclear protein; Transcription factor; Acetylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006960788,0.0004225536,0.0002983442,0.0004936386,0.0001158359,0.0002428528,0.0002353045,0.0002532179,0.002179117],"category_scores_gemma":[0.00005705365,0.0001560962,0.0002727406,0.0003240878,0.0001897574,0.0001090528,0.0001449102,0.0006622201,0.0004697217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003063695,"about_ca_system_score_gemma":0.0002552898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000805857,"about_ca_topic_score_gemma":0.001904523,"domain_scores_codex":[0.9999046,0.000008727457,0.000003751829,0.000023466,0.00002419653,0.00003530614],"domain_scores_gemma":[0.9999663,0.000004776721,0.00001000549,0.000003635463,0.00000371013,0.00001157304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000243779,0.0001080887,0.0001007601,0.00005083913,0.000009587372,0.00004006959,0.0000122015,0.0003897446,0.9937062,0.0002058722,0.0002352395,0.004897729],"study_design_scores_gemma":[0.00008369286,0.001058917,0.002723898,0.000006944859,0.00005194328,0.0001367989,0.00002327975,0.002280938,0.9876216,0.00008076459,0.005924813,0.000006388185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853592,0.002148097,0.005951575,0.0002515377,0.00007813006,0.0002240598,0.00192116,0.0008579619,0.003208305],"genre_scores_gemma":[0.9869699,0.001007083,0.004381703,0.00008579031,0.000007759839,0.0001378356,0.001594893,0.00006374909,0.005751269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002179117,"threshold_uncertainty_score":0.007289886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01904423462046446,"score_gpt":0.2720036081499647,"score_spread":0.2529593735295003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}