{"id":"W2984805909","doi":"10.1016/j.biopsych.2019.10.015","title":"The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls","year":2019,"lang":"en","type":"review","venue":"Biological Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Drug Abuse; National Institute of Mental Health; National Health and Medical Research Council; Stanley Center for Psychiatric Research, Broad Institute; University of California, San Diego; National Institutes of Health; H. Lundbeck A/S; Medical Research Council; Servier; Siemens Healthineers; National Institute on Aging; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Chinese Society of Clinical Oncology; Novo Nordisk Fonden; NSW Ministry of Health; Rheinische Friedrich-Wilhelms-Universität Bonn; Vetenskapsrådet; Region Hovedstaden; Novo Nordisk; European Regional Development Fund; Universitat de Barcelona; King's College London; Max-Planck-Gesellschaft; Stanley Medical Research Institute; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Center for Individualized Medicine, Mayo Clinic; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya; Generalitat de Catalunya; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Universität Greifswald; Agence Nationale de la Recherche; Canadian Institutes of Health Research; Office of Health and Medical Research; Università di Bologna; AstraZeneca; European Commission; Scottish Funding Council; Department of Health and Social Care; Broad Institute; QIMR Berghofer Medical Research Institute; Norges Forskningsråd; Erasmus Medisch Centrum; Stiftelsen för Strategisk Forskning; Neuroscience Research Australia; Wellcome Trust; National Institute on Alcohol Abuse and Alcoholism; Stockholms Läns Landsting; Højteknologifonden; U.S. Department of Health and Human Services; GlaxoSmithKline; Mayo Clinic; Wayne and Gladys Valley Foundation; Departament de Salut, Generalitat de Catalunya; National Science Foundation; University of Michigan; Lundbeckfonden; Centro de Investigación Biomédica en Red de Salud Mental; Eli Lilly and Company; Kaiser Permanente; State University of New York; Maudsley Charity; Westfälische Wilhelms-Universität Münster; Instituto de Salud Carlos III; Ellison Medical Foundation; Janssen Research and Development; ZonMw; National Alliance for Research on Schizophrenia and Depression; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Cilag; Robert Wood Johnson Foundation; Sunovion; Pfizer","keywords":"Genome-wide association study; Association (psychology); Genetics; Mood; Psychology; Genetic association; Clinical psychology; Psychiatry; Biology; Genotype; Psychotherapist; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003145061,0.0004617716,0.0008766956,0.001513616,0.0009247542,0.001048487,0.0005451488,0.0007796814,0.001487522],"category_scores_gemma":[0.003826733,0.0006210962,0.00162379,0.003311928,0.000414564,0.0002690907,0.0007829044,0.0006347093,0.0001779647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004455266,"about_ca_system_score_gemma":0.0004570283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01391942,"about_ca_topic_score_gemma":0.01391153,"domain_scores_codex":[0.9972875,0.0007801788,0.0002793166,0.001155435,0.0003340751,0.0001635965],"domain_scores_gemma":[0.998404,0.0005607531,0.0004446769,0.0003042604,0.0001522263,0.0001341545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0007310465,0.0000503793,0.9868006,0.0001151255,0.005662353,0.0004089862,0.0001731211,0.0001787548,0.001473085,0.0000878608,0.0007855534,0.003533037],"study_design_scores_gemma":[0.0001293884,0.00007597556,0.9957187,0.00002388763,0.002385927,0.0003733421,0.00009947446,0.0002315311,0.000118018,0.00007471853,0.0007610686,0.000007948858],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9905726,0.004298472,0.000982221,0.0001653954,0.00003147401,0.00003169661,0.00343694,0.00003429218,0.0004468163],"genre_scores_gemma":[0.9962211,0.0007151684,0.0006829448,0.00008637226,0.00002705721,0.00003989707,0.002018968,0.00001306427,0.0001954725],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01391942,"threshold_uncertainty_score":0.02767676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04903116830843365,"score_gpt":0.3467602341123688,"score_spread":0.2977290658039352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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