{"id":"W2984805909","doi":"10.1016/j.biopsych.2019.10.015","title":"The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls","year":2019,"lang":"en","type":"review","venue":"Biological Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Drug Abuse; National Institute of Mental Health; National Health and Medical Research Council; Stanley Center for Psychiatric Research, Broad Institute; University of California, San Diego; National Institutes of Health; H. Lundbeck A/S; Medical Research Council; Servier; Siemens Healthineers; National Institute on Aging; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Chinese Society of Clinical Oncology; Novo Nordisk Fonden; NSW Ministry of Health; Rheinische Friedrich-Wilhelms-Universität Bonn; Vetenskapsrådet; Region Hovedstaden; Novo Nordisk; European Regional Development Fund; Universitat de Barcelona; King's College London; Max-Planck-Gesellschaft; Stanley Medical Research Institute; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Center for Individualized Medicine, Mayo Clinic; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya; Generalitat de Catalunya; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Universität Greifswald; Agence Nationale de la Recherche; Canadian Institutes of Health Research; Office of Health and Medical Research; Università di Bologna; AstraZeneca; European Commission; Scottish Funding Council; Department of Health and Social Care; Broad Institute; QIMR Berghofer Medical Research Institute; Norges Forskningsråd; Erasmus Medisch Centrum; Stiftelsen för Strategisk Forskning; Neuroscience Research Australia; Wellcome Trust; National Institute on Alcohol Abuse and Alcoholism; Stockholms Läns Landsting; Højteknologifonden; U.S. Department of Health and Human Services; GlaxoSmithKline; Mayo Clinic; Wayne and Gladys Valley Foundation; Departament de Salut, Generalitat de Catalunya; National Science Foundation; University of Michigan; Lundbeckfonden; Centro de Investigación Biomédica en Red de Salud Mental; Eli Lilly and Company; Kaiser Permanente; State University of New York; Maudsley Charity; Westfälische Wilhelms-Universität Münster; Instituto de Salud Carlos III; Ellison Medical Foundation; Janssen Research and Development; ZonMw; National Alliance for Research on Schizophrenia and Depression; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Cilag; Robert Wood Johnson Foundation; Sunovion; Pfizer","keywords":"Genome-wide association study; Association (psychology); Genetics; Mood; Psychology; Genetic association; Clinical psychology; Psychiatry; Biology; Genotype; Psychotherapist; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006329138,0.0003741506,0.001241751,0.00003953492,0.0001688486,0.00001686554,0.0005598739,0.0008904831,0.0000152065],"category_scores_gemma":[0.001317579,0.0001858999,0.000730415,0.0001871034,0.0002778478,0.000001524684,0.0002760912,0.0002625712,0.000003122276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003437012,"about_ca_system_score_gemma":0.0001806085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006437463,"about_ca_topic_score_gemma":0.0001664899,"domain_scores_codex":[0.9972594,0.0007491449,0.000951198,0.0004943038,0.0001624287,0.0003835755],"domain_scores_gemma":[0.9967178,0.0009283447,0.001505684,0.0006920947,0.00009757148,0.00005848449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003692989,0.0001530498,0.9801768,0.0006358594,0.001353158,2.062024e-7,0.00001073328,0.00003889461,0.0001214027,0.00009693199,0.00137643,0.01599962],"study_design_scores_gemma":[0.0004595632,0.0005863347,0.4722425,0.0002251334,0.001042939,0.00001068374,0.00009044155,0.000007836896,0.00001232675,0.0004725073,0.5244614,0.0003882709],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08839122,0.9092305,0.0000361863,0.0005504421,0.0004654746,0.0006906203,0.0004595511,0.00000544894,0.0001705146],"genre_scores_gemma":[0.09661189,0.9022276,0.0001494075,0.0001593321,0.0002698836,0.00004097041,0.0001992116,0.00002292948,0.000318798],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5230851,"threshold_uncertainty_score":0.7580779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04903116830843365,"score_gpt":0.3467602341123688,"score_spread":0.2977290658039352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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