{"id":"W2984890091","doi":"10.1182/blood-2019-130337","title":"A Phase I/II Study to Investigate the Safety and Clinical Activity of the Protein Arginine Methyltransferase 5 Inhibitor GSK3326595 in Subjects with Myelodysplastic Syndrome and Acute Myeloid Leukemia","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Myelodysplastic syndromes; Myeloid leukemia; Protein arginine methyltransferase 5; Cancer research; Myeloid; Chronic myelomonocytic leukemia; Population; Methyltransferase; Leukemia; Medicine; Biology; Immunology; Methylation; Bone marrow; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001292051,0.001274784,0.001663603,0.0004127556,0.0003886613,0.0004954793,0.0006096942,0.001242767,0.006204052],"category_scores_gemma":[0.0005803378,0.0004472293,0.0009562921,0.0003317758,0.0006899955,0.0005162794,0.0002928625,0.001903315,0.001266428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006320149,"about_ca_system_score_gemma":0.001615157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007551429,"about_ca_topic_score_gemma":0.002295715,"domain_scores_codex":[0.9996506,0.0001467009,0.0000192353,0.00007016255,0.00003405423,0.00007923059],"domain_scores_gemma":[0.9993648,0.00007497625,0.00009848904,0.00004220879,0.00006092999,0.0003586365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7073476,0.08307044,0.01528047,0.001528226,0.00160068,0.0006949895,0.000250659,0.00157304,0.0682654,0.0006185073,0.008212161,0.1115579],"study_design_scores_gemma":[0.4542195,0.526818,0.009292785,0.00004407643,0.0004815896,0.0003564409,0.00006357358,0.0005242325,0.002873493,0.0003074073,0.004999882,0.00001901258],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786453,0.003650414,0.001097936,0.0007906697,0.0002085508,0.009046945,0.002604055,0.0001552156,0.00380086],"genre_scores_gemma":[0.9743052,0.002199697,0.003430064,0.00221213,0.000236153,0.008818502,0.003456343,0.00002812229,0.005313818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006204052,"threshold_uncertainty_score":0.02075458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00679248078787135,"score_gpt":0.2529946812124443,"score_spread":0.2462022004245729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}