{"id":"W2984890091","doi":"10.1182/blood-2019-130337","title":"A Phase I/II Study to Investigate the Safety and Clinical Activity of the Protein Arginine Methyltransferase 5 Inhibitor GSK3326595 in Subjects with Myelodysplastic Syndrome and Acute Myeloid Leukemia","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Myelodysplastic syndromes; Myeloid leukemia; Protein arginine methyltransferase 5; Cancer research; Myeloid; Chronic myelomonocytic leukemia; Population; Methyltransferase; Leukemia; Medicine; Biology; Immunology; Methylation; Bone marrow; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004249054,0.0001649628,0.0002599021,0.00003779108,0.00006998805,0.00001233679,0.0001215056,0.0001012379,0.000002084832],"category_scores_gemma":[0.00007065743,0.0001009179,0.00003907211,0.0002242318,0.0001546265,0.000007663103,0.0001478254,0.0001969382,6.312305e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001728244,"about_ca_system_score_gemma":0.0002059735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006604057,"about_ca_topic_score_gemma":0.0004803054,"domain_scores_codex":[0.9987977,0.0002213864,0.0002668007,0.0003921636,0.0001536783,0.0001682603],"domain_scores_gemma":[0.9993579,0.00004207822,0.00009502482,0.0003829658,0.00003934796,0.00008272347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001893976,0.0009704891,0.02145892,0.00003406194,0.0003165748,0.000008009712,0.0003699834,0.0001239598,0.9733565,0.000005504402,0.000004144745,0.00145786],"study_design_scores_gemma":[0.01948412,0.01417409,0.2923886,0.0001620723,0.0003998168,0.0001065648,0.0001171419,0.0001542776,0.672596,0.00001352189,0.0001144055,0.000289385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976326,0.0001236093,0.00004035606,0.0002686981,0.00005220546,0.001836689,0.00002680915,0.000005687987,0.0000133047],"genre_scores_gemma":[0.9996476,0.00003501747,0.00007860915,0.00003859355,0.00003926531,0.00003845147,0.000005764533,0.00001872467,0.00009793039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3007605,"threshold_uncertainty_score":0.4115314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00679248078787135,"score_gpt":0.2529946812124443,"score_spread":0.2462022004245729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}