{"id":"W2985018913","doi":"10.1194/jlr.ra119000424","title":"Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling","year":2019,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Fonds Baillet Latour; Natural Sciences and Engineering Research Council of Canada; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Compute Canada; Canadian Institutes of Health Research; Walloon excellence in life sciences and biotechnology; Canada Excellence Research Chairs, Government of Canada; European Research Council; Université Laval; Fonds De La Recherche Scientifique - FNRS; Australian Government; Social Sciences and Humanities Research Council of Canada","keywords":"Biology; Microbiome; Gut flora; Lipidomics; Transcriptome; Ileum; Lipid metabolism; Gastrointestinal tract; Lipid signaling; Gut–brain axis; Cell biology; Endocannabinoid system; Dysbiosis; Receptor; Immunology; Gene expression; Inflammation; Gene; Genetics; Endocrinology; Bioinformatics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029529,0.0009986089,0.0006423279,0.001341695,0.0002998289,0.0006208126,0.0003554721,0.0009718743,0.00227327],"category_scores_gemma":[0.0003132886,0.0004259057,0.0006836909,0.0003957832,0.000863352,0.0005446858,0.000553248,0.002148591,0.0005464801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003177535,"about_ca_system_score_gemma":0.0002749368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005218603,"about_ca_topic_score_gemma":0.0008482448,"domain_scores_codex":[0.9993839,0.00006556669,0.00006913621,0.0002137731,0.0001266816,0.0001410072],"domain_scores_gemma":[0.9991205,0.00006268157,0.000366723,0.00009204942,0.00004922598,0.0003088006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006654415,0.0001084197,0.0006666735,0.00004213355,0.00001370879,0.0001465546,0.0000330287,0.00003350308,0.996911,0.00009345892,0.0000520086,0.001234244],"study_design_scores_gemma":[0.0001948283,0.003102611,0.0897277,0.00006446723,0.0001258494,0.002231038,0.000389579,0.001045966,0.8984753,0.0005065001,0.004079143,0.00005713403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935861,0.001025036,0.002412582,0.0001848864,0.00006212616,0.00003401513,0.001572051,0.0002429097,0.0008802688],"genre_scores_gemma":[0.9863529,0.00121915,0.005072569,0.0002916867,0.00004162066,0.0001592268,0.001902772,0.0001767485,0.004783288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00227327,"threshold_uncertainty_score":0.007604837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04265540082385487,"score_gpt":0.3607347013546277,"score_spread":0.3180793005307728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}