{"id":"W2985018913","doi":"10.1194/jlr.ra119000424","title":"Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling","year":2019,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Fonds Baillet Latour; Natural Sciences and Engineering Research Council of Canada; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Compute Canada; Canadian Institutes of Health Research; Walloon excellence in life sciences and biotechnology; Canada Excellence Research Chairs, Government of Canada; European Research Council; Université Laval; Fonds De La Recherche Scientifique - FNRS; Australian Government; Social Sciences and Humanities Research Council of Canada","keywords":"Biology; Microbiome; Gut flora; Lipidomics; Transcriptome; Ileum; Lipid metabolism; Gastrointestinal tract; Lipid signaling; Gut–brain axis; Cell biology; Endocannabinoid system; Dysbiosis; Receptor; Immunology; Gene expression; Inflammation; Gene; Genetics; Endocrinology; Bioinformatics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.005173589,0.0002293515,0.0007375719,0.001379753,0.0001782145,0.0001423432,0.0008206985,0.0001570359,0.001699658],"category_scores_gemma":[0.001884049,0.0001787796,0.0003960776,0.0009610311,0.0003714467,0.0002884784,0.0004058216,0.002161511,0.0001200152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004650328,"about_ca_system_score_gemma":0.002420105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001074692,"about_ca_topic_score_gemma":0.00001514635,"domain_scores_codex":[0.994351,0.0004778967,0.001256793,0.0003636801,0.002677242,0.0008733552],"domain_scores_gemma":[0.9933966,0.00021608,0.0004613987,0.0007411328,0.004655011,0.0005297256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000854441,0.0005725804,0.004580449,0.000587952,0.0001363224,0.0002067065,0.0004584171,0.00006710524,0.9153326,0.0002379061,0.07572836,0.001237168],"study_design_scores_gemma":[0.01715135,0.01425124,0.04667065,0.003741562,0.0002402759,0.009061124,0.004724522,0.0005852977,0.692145,0.001004252,0.2096015,0.0008232502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792626,0.001060736,0.00008444936,0.01418759,0.0005125434,0.0009762518,0.00002363411,0.0000124349,0.003879771],"genre_scores_gemma":[0.9605616,0.000145093,0.001197198,0.0001216891,0.001603298,0.00002172859,0.000007449236,0.00005864825,0.03628331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2231876,"threshold_uncertainty_score":0.9992129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04265540082385487,"score_gpt":0.3607347013546277,"score_spread":0.3180793005307728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}